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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Study period:
December 1969
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
comparable to guideline study with acceptable restrictions
Remarks:
The study meets the EC Standards (conducted equivalent to OECD 403). Non GLP.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1969
Report date:
1969

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 403 (Acute Inhalation Toxicity)
Deviations:
yes
Remarks:
no details on environmental conditions, no analytical data on the maximum attainable concentration.
GLP compliance:
no
Remarks:
not present at the time of performance.
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Reference substance name:
Reaction products of pentaerythritol, propoxylated and 1-chloro-2,3-epoxypropane with hydrogen sulfide
EC Number:
701-196-7
Cas Number:
72244-98-5
Molecular formula:
not applicable
IUPAC Name:
Reaction products of pentaerythritol, propoxylated and 1-chloro-2,3-epoxypropane with hydrogen sulfide
Test material form:
other: liquid
Details on test material:
- Name of test material (as cited in study report): DION® Polymercaptan Resin DPM 3-800LC
- Description: viscous, amber liquid

Test animals

Species:
rat
Strain:
other: albino Charles River strain
Sex:
male/female
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: Charles River
- Age at study initiation: no data
- Weight at study initiation: 200 g (average)
- Housing: individually in stock cages
- Diet: free access to standard laboratory diet (Purina Rat Chow)
- Water: free access to water
- Acclimation period: at least five days

ENVIRONMENTAL CONDITIONS
No data

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
whole body
Vehicle:
clean air
Details on inhalation exposure:
GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: Vapor generator
- Exposure chamber volume: 70 L
- Method of holding animals in test chamber: Each animal was caged separately
- Source and rate of air: 4.0 L/min
- Temperature, humidity, pressure in air chamber: 26°C and the pressure was 29. 79 inches Hg

TEST ATMOSPHERE
- Brief description of analytical method used: no data
- Samples taken from breathing zone: no

Analytical verification of test atmosphere concentrations:
not specified
Remarks:
Average nominal vapor concentration was calculated by dividing the generator weight loss by the total volume of air used during the test.
Duration of exposure:
4 h
Concentrations:
0.1 mg/L (nominal), 99% of maximum vapor concentration was established.
No. of animals per sex per dose:
5
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 14 days
- Frequency of observations and weighing:
Body weights were determined prior to inhalation exposure and for each surviving animal at the end of the 14-day observation period.
- Necropsy of survivors performed: yes

Results and discussion

Effect levels
Key result
Sex:
male/female
Dose descriptor:
LC50
Effect level:
> 0.1 mg/L air (nominal)
Based on:
test mat.
Mortality:
No deaths occurred.
Clinical signs:
other: No data.
Body weight:
No adverse effects were observed (results not included).
Gross pathology:
No abnormalities were observed.

Applicant's summary and conclusion

Interpretation of results:
other: not classified according to Regulation (EC) No 1272/2008
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
In an acute inhalation toxicity study with male and female rats, performed equivalent to OECD 403 guideline, an LC50 > 0.1 mg/L air was determined.
Executive summary:

The test substance DPM 3 -800LC was tested in an acute inhalation toxicity study with male and female rats, performed equivalent to OECD 403 guideline. Concentration of 0.1 mg/L (nominal), 99% of maximum vapor concentration was established. No deaths occurred. At gross pathology no abnormalities were observed.

Based on the results, an LC50 > 0.1 mg/L air was determined.