Tetrachlorophthalic anhydride

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: secondary literature

Data source

Reference

Reference Type:

review article or handbook

Title:

Unnamed

Year:

1975

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 403 (Acute Inhalation Toxicity)

Principles of method if other than guideline:

Groups of 5 male and 5 female rats were exposed to atmospheres containing either 3.16 or 3.60 mg/l tetrachlorophthalic anhydride for 4 hrs. Animals were held for 14 days for observation, and clinical signs were recorded. After the termination of the study the animals were sacrifieced and a necropsy performed.

GLP compliance:

not specified

Test type:

standard acute method

Test material

Test material information

Constituent 1

Reference substance name:

Tetrachlorophthalic anhydride

EC Number:

204-171-4

EC Name:

Tetrachlorophthalic anhydride

Cas Number:

117-08-8

Molecular formula:

C8Cl4O3

IUPAC Name:

tetrachloro-1,3-dihydro-2-benzofuran-1,3-dione

Specific details on test material used for the study:

Greater than 43 % of the dust particles were < 5 microns in diameter, and > 65% were less than 10 microns.

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Administration / exposure

Route of administration:

inhalation: dust

Type of inhalation exposure:

whole body

Vehicle:

clean air

Analytical verification of test atmosphere concentrations:

yes

Duration of exposure:

4 h

Concentrations:

3.16 or 3.60 mg/l. test material

No. of animals per sex per dose:

5 males and 5 females/dose

Control animals:

not specified

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LC0

Effect level:

> 3.6 mg/L air

Based on:

test mat.

Exp. duration:

4 h

Any other information on results incl. tables

No deaths occurred at either test level. 3.6 mg/L was determined to be the maximum attainable concentration using this equipment. No untoward reactions were observed during the exposure or observation periods nor were there any alterations attributable to test material seen at necropsy.

Applicant's summary and conclusion

Executive summary:

Groups of 5 male and 5 female rats were exposed to atmospheres containing either 3.16 or 3.60 mg/l. test material for 4 hrs. Air concentrations were generated using a ferris wheel generator to create a dust and passing clean air through the generator at 30 L/min. to an 80 L. glass and steel chamber containing the animals. Particle size means were calculated. Rats were held for 14 days for observation, then sacrificed and necropsied. Physical signs were recorded.

No deaths occurred at either test level. 3.6 mg/L was determined to be the maximum attainable concentration using this equipment. No untoward reactions were observed during the exposure or observation periods nor were there any alterations attributable to test material seen at necropsy. LC0 > 3.6 mg/l (rat, male + female).