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Vapour pressure

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Reference
Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2014-02-24 to 2014-04-09
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study with acceptable restrictions
Remarks:
The study was conducted according to OECD/EC guideline, and under GLP. Test substance is adequately specified with purity. However validation applies with minor restrictions, due to technical inaccuracy (distant extrapolation).
Qualifier:
according to guideline
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.4 (Vapour Pressure)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EPA OPPTS 830.7950 (Vapor Pressure)
Principles of method if other than guideline:
Not applicable
GLP compliance:
yes (incl. QA statement)
Remarks:
inspected on January 22 and 23, 2013 / signed on March 22, 2013
Type of method:
dynamic method
Key result
Temp.:
20 °C
Vapour pressure:
36 Pa
Remarks on result:
other: extrapolated
Temp.:
25 °C
Vapour pressure:
50 Pa
Remarks on result:
other: extrapolated
Temp.:
50 °C
Vapour pressure:
234 Pa
Remarks on result:
other: extrapolated

Thermal Stability:

The test item showed no thermal effects up to the maximum test temperature of 300 °C.

 

Dynamic method: vapour-liquid equilibrium

The vapour pressure was measured in the temperature range of 86.1 to 181.8°C.

Table 4.6/1: Results of the dynamic method

No.

Temperature (°C)

Vapour pressure (hPa)

Remark

1

86.1

15

measured up

2

102.5

30

measured up

3

119.7

60

measured up

4

138.2

120

measured up

5

158.8

240

measured up

6

181.8

480

measured up

7

166.0

300

measured down

8

133.1

100

measured down

9

92.5

20

measured down

 

From the measured data points of the vapour pressure curve, the constants A, B and C of the Antoine equation

log10 P = A + B / (C+T)

can be derived by regression:

A = 10.3432

B = -2576.59

C = 273.15

 

The vapour pressure of the test item calculated by extrapolation of the measured vapour pressure curve for the temperatures 20, 25 and 50 °C were 0.36, 0.50 and 2.34 hPa, respectively.

Conclusions:
Low volatility (based on volatility bands criteria for occupational exposure (Chesar / ECETOC TRA), < 500 Pa).
Executive summary:

The vapour pressure of the test substance was measured under GLP according to OECD 104 / EU A4 guideline by dynamic method.

A preliminary stability test by DSC showed no thermal effects up to the maximum test temperature of 300 °C.

A series of nine measurements was recorded between 15 and 480 hPa, corresponding to 86 to 182°C. The vapour pressure of the test item was extrapolated from the regression to be 36 Pa at 20°C, and 50 Pa at 25°C.

Description of key information

(extrapolated) Low volatility.

Key value for chemical safety assessment

Vapour pressure:
36 Pa
at the temperature of:
20 °C

Additional information

A reliable experimental study, conducted according to a recognized OECD/EU method, is available. Despite minor restrictions for accuracy, due to distant extrapolation, it is considered as a key study. The result is retained as key data.