Registration Dossier

Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2016
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2016

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Deviations:
no
GLP compliance:
yes (incl. certificate)
Type of method:
HPLC method
Partition coefficient type:
octanol-water

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
liquid

Study design

Analytical method:
high-performance liquid chromatography

Results and discussion

Partition coefficient
Key result
Type:
log Pow
Partition coefficient:
5.3 - 6.6
Temp.:
35 °C
pH:
7

Applicant's summary and conclusion

Conclusions:
log Pow= 5.3; 5.9* and 6.6*
* indicative values, peaks are outside calibration domain
Executive summary:

The Partition Coefficient n-octanol/water of GR-86-6599 was determined by the Reverse Phase High Performance Liquid Chromatographic Method according to the OECD Guidelines for Testing of Chemicals, Method No. 117.

 

The result is:

Partition coefficients n-octanol/water of GR-86-6599:     

 

 

log Pow= 5.3; 5.9* and 6.6*

                

 

* indicative values, peaks are outside calibration domain