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EC number: 903-812-1 | CAS number: -
There was no effect of isobutylene on the number, growth or survival of the foetuses in utero.
There was no effect of isobutylene on foetal development. Although cleft sternebrae were observed only in foetuses in the isobutylene groups, the incidence of foetuses affected was small and not dose-related and there were no minor changes in the appearance or ossification of the sternebrae to indicate that this area of the skeleton was adversely affected by isobutylene. Also, there was no evidence for an adverse effect of isobutylene on other ossification centres of the skeleton. Isolated differences from control were considered to be incidental. Thus isobutylene at exposure concentrations of up to 8000 ppm, is considered not to have any adverse effect on foetal development.
Pregnant rats were exposed to isobutylene (2-methylpropene) at exposure concentrations of 500, 2000 and 8000 ppm (1147, 4589, 18359 mg/m3), from gestation day 5-21. Isobutylene had no effect on the females during gestation. There was no effect of isobutylene on the number, growth or survival of the foetuses in utero and no effect on foetal development. The NOECs for maternal and developmental toxicity were 8000 ppm (18359 mg/m3), the highest concentration tested.
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