Registration Dossier
Registration Dossier
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EC number: 203-728-9 | CAS number: 110-01-0
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
In the key study (Bottcher 2009), the toxicity of tetrahydrothiophene to Danio rerio was not precisely determined as only one dose was used. The NOEC is 24 mg/L for Danio rerio and therefore demonstrates that fish are less sensitive than Daphnia.
Key value for chemical safety assessment
Additional information
Bottcher (2009) is a GLP-compliant study following OECD guideline 203. However, only one dose concentration is used, which means that the results are not precise. The dose concentration was chosen as the threshold concentration of 24 mg/l, which was the lowest relevant, existing EC50 value for acute algae or daphnia. This shows that Daphnia are more sensitive to tetrahydrothiophene than fish. The results are considered reliable and suitable for use for this endpoint.
The supporting study (Kuttler 1998) is a semi-static, 96 hour, GLP-compliant study which follows OECD guideline 203. Test media were prepared as WAF, but included analytical measurement of the exposure concentrations. The large spacing between the test concentrations means that the LC50 cannot be precisely determined. The LC0 is reported as 15 mg/l and the LC100 as 6128 mg/l.
Neither of these studies allow us to determine an LC50, however, Bottcher (2009) does demonstrate that fish are less sensitive to tetrahydrothiophene than Daphnia. Due to this, conducting a new acute fish study is not considered necessary.
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