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EC number: 217-703-5
CAS number: 1934-75-4
In an acute oral toxicity study using albino rats, the oral LD50
was 725 mg/kg bw (95% CL: 605 -875 mg/kg bw) in males and 775.0 mg/kg bw
in females (95% CL: 670.0 - 895.0 mg/kg bw). The study has been
conducted before implementation of GLP.
Additionally, handbook data indicate that the oral LD50 in mice
was about 1000 mg/kg and the intraperitoneal LD50 610 mg/kg.
Table 1: Experimental data:
Dose level mg/ kg bw
No. of male rats
Day of deaths
No. of female rats
Males: At 250 mg/kg, the animals were languid
with nasal haemorrhage and ruffled, unkempt coats. The animals dosed at
500, 630, 800 and 1000 mg/kg were lethargic with very ruffled, unkempt
coats. Within one hour, all animals were crouched in a fetal position.
At this time, ocular and nasal haemorrhage were first evident.
Convulsions began about 2-2.5 hours after intubation. Survivors remained
unkempt throughout the observation period. Symptoms of toxicity at 2000
mg/kg were the same as at 1000 mg/kg except for their severity. All
animals succumbed within 2 hours.
Females: Nasal haemorrhage, sluggish
locomotion and ruffled, unkempt coats were noted at 250 mg/kg. At dosage
level of 500 mg/kg, 630 mg/kg and 800 mg/kg, the animals were lethargic
with ruffled, unkempt coats. Spasmodic movements were noted. Within an
hour, all animals were in a fetal position. Lacrimation, ocular and
nasal haemorrhage were noted. Convulsions began approximately two hours
after dosing. The animals dosed at 1000 mg/kg and 2000 mg/kg showed the
same toxicity as at 800 mg/kg. All animals died within 2 -4 hours after
In an acute oral toxicity, groups of fasted male and female albino
rats were given a single oral dose of sodium dicyanoamide
in propylene glycol at doses of 250, 500, 630, 800, 1000 and 2000 mg/kg
bw. The animals were observed daily for a two-week period.
The oral LD50 in males was 725 mg/kg bw (95% CL: 605 -875 mg/kg
bw) and 775.0 mg/kg bw in females (95% CL: 670.0 - 895.0 mg/kg bw).
All animals died at a dose of 1000 mg/kg bw and higher. At lower
doses, symptoms like unkempt coats, lethargy, convulsions and
haemorrhage were observed.
The LD50 value of the test item is 725 mg/kg bw in male albino
rats, therefore the test item will be classiﬁed as acute toxic; category
4; oral, H302 according to GHS/CLP classiﬁcation criteria.
According to a publication which has been cited in the handbook "Patty’s
Toxicology, Sixth Edition. Volume 2", the oral LD50 of sodium
dicyanoamide in mice is about 1000 mg/kg and the intraperitoneal LD50
The original report as cited in the handbook was not avaible and thus,
details on the experimental procedure are lacking.
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