Registration Dossier

Administrative data

First-aid measures

General advice: First Aid responders should pay attention to self-protection and use the recommended protective clothing (chemical resistant gloves, splash protection).

Inhalation: Move person to fresh air; if effects occur, consult a physician.

Skin contact: Wash off with plenty of water.

Eye contact: Flush eyes thoroughly with water for several minutes. Remove contact lenses after the initial 1-2 minutes and continue flushing for several additional minutes. If effects occur, consult a physician, preferably an ophthalmologist.

Ingestion: Do not induce vomiting. Seek medical attention immediately. If person is fully conscious give 1 cup or 8 ounces (240 ml) of water. If medical advice is delayed and if an adult has swallowed several ounces of chemical, then give 3-4 ounces (1/3-1/2 Cup) (90-120 ml) of hard liquor such as 80 proof whiskey. For children, give proportionally less liquor at a dose of 0.3 ounce (1 1/2 tsp.) (8 ml) liquor for each 10 pounds of body weight, or 2 ml per kg body weight [e.g., 1.2 ounce (2 1/3 tbsp.) for a 40 pound child or 36 ml for an 18 kg child].

Notes to physician: Skin contact may aggravate preexisting dermatitis. Due to structural analogy and clinical data, this material may have a mechanism of intoxication similar to ethylene glycol. On that basis, treatment similar to ethylene glycol intoxication may be of benefit. In cases where several ounces (60 - 100 ml) have been ingested, consider the use of ethanol and hemodialysis in the treatment. Consult standard literature for details of treatment. If ethanol is used, a therapeutically effective blood concentration in the range of 100 - 150 mg/dl may be achieved by a rapid loading dose followed by a continuous intravenous infusion. Consult standard literature for details of treatment. 4-Methyl pyrazole (Antizol®) is an effective blocker of alcohol dehydrogenase and should be used in the treatment of ethylene glycol (EG), di- or triethylene glycol (DEG, TEG), ethylene glycol butyl ether (EGBE), or methanol intoxication if available. Fomepizole protocol (Brent, J. et al., New England Journal of Medicine, Feb. 8, 2001, 344:6, p. 424-9): loading dose 15 mg/kg intravenously, follow by bolus dose of 10 mg/kg every 12 hours; after 48 hours, increase bolus dose to 15 mg/kg every 12 hours. Continue fomepizole until serum methanol, EG, DEG, TEG or EGBE are undetectable. The signs and symptoms of poisoning include anion gap metabolic acidosis, CNS depression, renal tubular injury, and possible late stage cranial nerve involvement. Respiratory symptoms, including pulmonary edema, may be delayed. Persons receiving significant exposure should be observed 24-48 hours for signs of respiratory distress. In severe poisoning, respiratory support with mechanical ventilation and positive end expiratory pressure may be required. Maintain adequate ventilation and oxygenation of the patient. If lavage is performed, suggest endotracheal and/or esophageal control. Danger from lung aspiration must be weighed against toxicity when considering emptying the stomach. If burn is present, treat as any thermal burn, after decontamination. Treatment of exposure should be directed at the control of symptoms and the clinical condition of the patient.

Fire-fighting measures

Suitable extinguishing media: Water fog or fine spray. Carbon dioxide fire extinguishers. Dry chemical fire extinguishers. Foam. Do not use direct water stream. May spread fire. Alcohol resistant foams (ATC type) are preferred. General purpose synthetic foams (including AFFF) or protein foams may function, but will be less effective.

Unsuitable extinguishing media: Do not use direct water stream.

Hazardous combustion products: During a fire, smoke may contain the original material in addition to combustion products of varying composition which may be toxic and/or irritating.

Unusual Fire and Explosion Hazards: Container may rupture from gas generation in a fire situation. Violent steam generation or eruption may occur upon application of direct water stream to hot liquids.

Fire Fighting Procedures: Keep people away. Isolate fire and deny unnecessary entry. Hand held dry chemical or carbon dioxide extinguishers may be used for small fires. Use water spray to cool fire exposed containers and fire affected zone until fire is out and danger of reignition has passed. Fight fire from protected location or safe distance. Consider the use of unmanned hose holders or monitor nozzles. Immediately withdraw all personnel from the area in case of rising sound from venting safety device or discoloration of the container. Burning liquids may be extinguished by dilution with water. Do not use direct water stream. May spread fire. Move container from fire area if this is possible without hazard. Burning liquids may be moved by flushing with water to protect personnel and minimize property damage.

Special protective equipment for firefighters: Wear positive-pressure self-contained breathing apparatus (SCBA) and protective fire fighting clothing (includes fire fighting helmet, coat, trousers, boots, and gloves). If protective equipment is not available or not used, fight fire from a protected location or safe distance.

Accidental release measures

Personal precautions, protective equipment and emergency procedures: Isolate area. Keep unnecessary and unprotected personnel from entering the area. Use appropriate safety equipment.

Environmental precautions: Prevent from entering into soil, ditches, sewers, waterways and/or groundwater.

Methods and materials for containment and cleaning up: Small spills: Absorb with materials such as: Sand. Vermiculite. Collect in suitable and properly labeled containers. Large spills: Contain spilled material if possible. Pump into suitable and properly labeled containers.

Handling and storage

Precautions for safe handling: Avoid contact with eyes, skin, and clothing. Do not swallow. Wash thoroughly after handling. Spills of these organic materials on hot fibrous insulations may lead to lowering of the autoignition temperatures possibly resulting in spontaneous combustion.

Conditions for safe storage: Store in the following material(s): Carbon steel. Stainless steel. Phenolic lined steel drums. Do not store in: Aluminum. Copper. Galvanized iron. Galvanized steel.

Storage temperature: 5 - 35 °C

Transport information

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Marine transport (IMDG)

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Exposure controls / personal protection

Stability and reactivity

Disposal considerations