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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: acceptable, well-documented study report which meets basic scientific principles

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1987
Report date:
1987

Materials and methods

Principles of method if other than guideline:
in vivo skin irritation study
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Sodium benzothiazol-2-yl sulphide
EC Number:
219-660-8
EC Name:
Sodium benzothiazol-2-yl sulphide
Cas Number:
2492-26-4
Molecular formula:
C7H4NS2.Na
IUPAC Name:
sodium 1,3-benzothiazole-2-thiolate
Details on test material:
sodium MBT, Lot.: 7E090-FP 8085-011-31, 45% solution, pH>12

Test animals

Species:
rabbit
Strain:
New Zealand White

Test system

Type of coverage:
semiocclusive
Preparation of test site:
other: intact skin
Vehicle:
unchanged (no vehicle)
Controls:
not required
Duration of treatment / exposure:
4 h
Observation period:
7 days
Number of animals:
6

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
other: 24, 48, 72 h
Score:
8
Max. score:
8
Reversibility:
not reversible
Remarks on result:
other: corrosive, 7 days (injury in depth)
Other effects:
corrosive after 7 days (cratering - injury in depth)

Any other information on results incl. tables

An erythema score of 4 and an edema score of 4 was found 1h, 24h, 48h and 72h in all rabbits after patch removal. After 168 hours reading/scoring was judged as corrosive with cratering and injury in depth.

Applicant's summary and conclusion

Interpretation of results:
corrosive
Remarks:
Migrated information
Executive summary:

Six New Zealand rabbits were applied 0.5 ml of undiluted sodium-mercaptobenzothiazole on the intact skin under semi-occlusive conditions for 4 hours. Skin reactions (erythema and edema) were scored according to Draize 1h, 24 h, 48h, 72 h and 168 h following patch removal.

An erythema score of 4 and an edema score of 4 was found 1h, 24h, 48h and 72h in all rabbits after patch removal. After 168 hours reading/scoring was judged as corrosive with cratering and injury in depth.

Therefor a classification as corrosive to skin (R34 causes burns) according to the classification criteria 67/548/EWG and regulation no. 1272/2008 (GHS) (skin corrosive category 1B, H 314: causes severe skin burns and eye damage) is justified as worst-case consideration because a differentiation between Skin Corrr.1C and Skin Corr.1B is not possible on the basis of the available data.

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