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Administrative data

Link to relevant study record(s)

Description of key information

The in-vitro study conducted on dermatomed pig skin with the test chemical [14C] 4-chlororesorcinol dissolved in the vehicle hydrogen peroxide and water indicates low dermal penetration of the test substance. Low absorption of the test chemical by the dermal route can be an indication of low bio-accumulation potential; though and in-vitro study result is insufficient to prove the same

Key value for chemical safety assessment

Bioaccumulation potential:
low bioaccumulation potential
Absorption rate - dermal (%):
14.2

Additional information

In vitro dermal/percutaneous absorption study with radiolabelled[14C] 4-chlororesorcinol was conducted ondermatomed pig skin, 380 μm thickness. The total recovery of radioactivity was 103% (with hydrogen peroxide) and 107% (without hydrogen peroxide).[14C] 4-chlororesorcinol dissolved in the vehicle hydrogen peroxide and water exhibited low dermal penetration of the test substance.