Registration Dossier
Registration Dossier
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EC number: 202-462-0 | CAS number: 95-88-5
Endpoint summary
Administrative data
Description of key information
Additional information
Short term toxicity to fish:
Fish Acute Toxicity test according to OECD Guideline 203 was conducted for 4-chlororesorcinol. The nominal concentration selected for the experiment were 6.25 mg/L, 12.5mg/L,25mg/L, 50mg/L, 100mg/L and Zebra fishes were exposed to these concentration for 96 hours. The fishes were moving slowly as compared to control. No mortalities were found in the control aquaria.
LC0 (96 hours) (highest loading at which no mortality was observed) = 12.5mg/L
LC50 (96 hours) Experimental =>12.5 mg/L & <25 mg/L.
LC100 (96 hours) (lowest loading at which 100% mortality was observed) = 25 mg/L.
Since 4-Chlororesorcinol is not readily biodegradable in nature, thus the test substance is likely to exhibit short-term toxicity to fish in aquatic chronic 3 category as per the CLP criteria.
Long term toxicity to fish:
The long term toxicity of 4-Chlororesorcinol was examined on species Cyprinus carpio for 4-7 days.The effective concentration EC50 is found to be 10-100 mg/l for4-Chlororesorcinol in fish (egg).
Short term toxicity to aquatic invertebrate:
The Lethal concentration (LC50) value of 4-Chlororesorcinol in aquatic invertebrate (Daphnia pulex) in 96 hrs study on the basis of mortality effect
is found to be 1 mg/L.
Short term toxicity to aquatic algae and cyanobacteria
The effect of test substance 4-chlororesorcinol, CAS No. 95-88-5 was studiedon the growth of fresh water green alga Chlorella vulgaris. The study was conducted following OECD guideline 201- Alga growth inhibition test. The test concentration chosen for the study were 6.25mg/l, 12.5mg/l, 25mg/l, 50 mg/l, 100 mg/l and 200mg/l. The test concentrations were prepared using stock solution of the test substance using mineral media.. The green alga was exposed to the test concentration for a period of 72 hours to observe average specific growth rate and % growth inhibition under the effect of test substance. EC50 calculated graphically through probit analysis was observed to be 54.606mg/l.
Therefore the EC50 was considered to be 54.606 mg/L for 4-Chlororesorcinol and it is not readily biodegradable in nature indicating that test substance is likely to exhibit toxicity to aquatic algae in aquatic chronic 3 category as per the CLP criteria.
Toxicity to microorganisms
In toxicity to microorganism study for 4-Chlororesorcinol the physiological effect was evaluated by using QSAR model, the effect concentration (EC50) of 4-Chlororesorcinol was estimated to be 4.914484978 mg/l for Vibrio fisheri.
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