Registration Dossier
Registration Dossier
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EC number: 701-197-2 | CAS number: -
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: peer-reviewed handbook
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Handbook of Filler, Extenders, and Diluents
- Author:
- Ash, I.
- Year:
- 2 007
- Bibliographic source:
- Edition 2, P76, Synapse Info Resources 2007.
Materials and methods
- Principles of method if other than guideline:
- As this information comes from a peer-reviewed handbook, no information is available on i.e. the methods and on the guidelines followed.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Reaction products of 2-(chloromethyl)oxirane and glycerol
- EC Number:
- 701-197-2
- Molecular formula:
- 6 individual glycidether components (Molecular range ca. 200 - 600 g/mol)
- IUPAC Name:
- Reaction products of 2-(chloromethyl)oxirane and glycerol
Constituent 1
Test animals / tissue source
- Species:
- other: not given
Results and discussion
In vivo
Results
- Irritation parameter:
- other: effects on eyes
- Reversibility:
- other: possible risks of irreversible effects
- Remarks on result:
- other: strongly irritating to eyes and skin
- Irritant / corrosive response data:
- strongly irritating to eyes and skin, possible risks of irreversible effects
Applicant's summary and conclusion
- Interpretation of results:
- other: Category 2 (irritating) based on EU GHS criteria
- Remarks:
- Migrated information Criteria used for interpretation of results: other: EU-GHS
- Conclusions:
- No information is available concerning animals or methods used, guidelines followed. However, as the information comes from a peer-reviewed handbook, the information is considered to be of the high quality (reliability Klimisch 2). For the test material it is stated that the substance is strongly irritating to eyes and skin, with possible risks of irreversible effects. The test material does require classification, according to regulation (EC) 1272/2008.
- Executive summary:
The Handbook of Filler, Extenders, and Diluents also gives some information about the eye irritating potential of 1,2,3 -propanetriol, glycidyl ethers (Handbook of Filler, Extenders, and Diluents, Ash, 2.nd Edition, 2007). There is stated that the substance is strongly irritating to eyes and skin, with possible risks of irreversible effects. No further details are given.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
