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EC number: 290-636-7
CAS number: 90194-27-7
The toxicity of the substance has been assessed by the repeated exposure over a period of 28-days by the three routes of exposure, oral, dermal and inhalation.
The repeat dose toxicity has been determined by subacute 28-day oral
toxicity studies by oral, dermal and inhalation exposure. Based on the
data available, the substance may have the potential for haemotological
effects with a reduction in cholesterol observed in one of the studies
by oral exposure. Affects observed in the repeat dose inhalation
toxicity study available demonstated enlarged lungs in high and
intermediate dose animals which are likely to be physical effects due to
the inhalation of mineral oil and not necessarily a direct toxicological
effect of the registered substance.
Furthermore, one dermal repeat dose study exists noting effects which
resulted in the Study Director being unable to assign a NOAEL. Due
consideration of these data has been taken, but the results are
considered not representative of the toxicological effects of the
substance since the observations have not been repeated in the remaining
study with dermal exposure, nor following exposure by oral and
inhalation routes which are generally considered to represent greater
systemic exposure routes. Furthermore, effects to the testes of male
rats were not been observed in the reproductive toxicity study. In
consequence, although data are not available to adequately determine the
cause of these effects, the fact that no similar observations have been
found in any other study undertaken is considered adequate justification
to regard these data as not representative of the toxicological profile
of the registered substance.
Notwithstanding these effects, no further effects were observed in the
studies and each study achieved a NOAEL. The data are therefore
considered adequate to assess the toxicological profile of the substance
and for the purposes of classification.
Based on the NOAEL values available from these data, the substance is
considered to be not classified under CLP.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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