Registration Dossier
Registration Dossier
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EC number: 290-636-7 | CAS number: 90194-27-7
Toxicity to microorganisms
Administrative data
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- other: Published report
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- The data is available from a WHO study on the activity of linear alkaryl sulphonates. Although data may be based upon reliable data, this cannot be determined directly from the WHO report. The data has, however, been evaluated by the WHO expert committee and is therefore considered to be of good quality and sound reliability for WHO to have selected the data. It is therefore considered suitable for the purposes of hazard assessment when considered in conjunction with the partial degradation observed in the the ready biodegradation study.
- Justification for data waiving:
- other:
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 996
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 209 (Activated Sludge, Respiration Inhibition Test
- Deviations:
- not specified
- GLP compliance:
- not specified
Test material
- Reference substance name:
- sodium salt of linear alkylbenzene sulfonates (LAS)
- IUPAC Name:
- sodium salt of linear alkylbenzene sulfonates (LAS)
- Details on test material:
- Sample is considered to be of the same chemical class as the registered substance
Constituent 1
Sampling and analysis
- Analytical monitoring:
- not specified
Test solutions
- Vehicle:
- not specified
Test organisms
- Test organisms (species):
- activated sludge
- Details on inoculum:
- At 50 mg/litre, nitrification was decreased in extended aeration units that were treating synthetic sewage (Janicke & Niemitz, 1973). A bacterium similar to Klebsiella pneumoniae isolated from sewage degraded LAS at a concentration of 10 ml/litre, but a concentration of 20 ml/litre inhibited the growth of the bacterium by 39% (Hong et al., 1984).
Study design
- Test type:
- not specified
- Water media type:
- freshwater
- Limit test:
- yes
- Post exposure observation period:
- no data
Test conditions
- Hardness:
- no data
- Test temperature:
- no data
- pH:
- no data
- Dissolved oxygen:
- no data
- Salinity:
- no data
- Reference substance (positive control):
- not specified
Results and discussion
Effect concentrations
- Duration:
- 8 h
- Dose descriptor:
- EC50
- Effect conc.:
- >= 3 200 - <= 5 000 mg/L
- Nominal / measured:
- not specified
- Conc. based on:
- not specified
- Basis for effect:
- growth inhibition
Any other information on results incl. tables
The 8-h EC50, based on specific growth rate, of Pseudomonas fluorescensin solutions of C11.1LAS under static conditions was 3200-5600 mg/litre (Canton & Slooff, 1982).
Applicant's summary and conclusion
- Validity criteria fulfilled:
- not specified
- Conclusions:
- Based on the evidence of partial degradation in the ready biodegradation study and data available from the WHO report ENVIRONMENTAL HEALTH CRITERIA 169 LINEAR ALKYLBENZENE SULFONATES AND RELATED COMPOUNDS the substance is considered to have a NOEC > 1000mg/l
- Executive summary:
There is evidence of partial biodegradation from the ready biodegradation data available that might suggest the substance is not overtly toxic to sewage sludge microorganisms and it is therefore considered that the study is not scientifically justified.
Nevertheless, data is available from a WHO study on the activity of linear alkaryl sulphonates. Although data may be based upon reliable data, this cannot be determined directly from the WHO report. The data has, however, been evaluated by the WHO expert committee and is therefore considered to be of good quality and sound reliability for WHO to have selected the data. It is therefore considered suitable for the purposes of hazard assessment when considered in conjunction with the partial degradation observed in the the ready biodegradation study.
Based on the evidence of partial degradation in the ready biodegradation study and data available from the WHO report ENVIRONMENTAL HEALTH CRITERIA 169 LINEAR ALKYLBENZENE SULFONATES AND RELATED COMPOUNDS the substance is considered to have a NOEC > 1000mg/l
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