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Ecotoxicological information

Short-term toxicity to fish

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Link to relevant study record(s)

Reference
Endpoint:
short-term toxicity to fish
Type of information:
experimental study
Adequacy of study:
key study
Study period:
from 2007-12-12 to 2008-03-17
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Use of solvents to increase exposure; Pre test for bioaccumulation study. This study was performed according to GLP and the methods applied are fully compliant with OECD TG 203.
Reference:
Composition 0
Qualifier:
according to
Guideline:
OECD Guideline 203 (Fish, Acute Toxicity Test)
Deviations:
no
GLP compliance:
yes (incl. certificate)
Test material information:
Composition 1
Specific details on test material used for the study:
Batch: L57020431
Analytical monitoring:
no
Vehicle:
yes
Details on test solutions:
According to guideline
PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Chemical name of vehicle (organic solvent, emulsifier or dispersant): Tween 80
- Concentration of vehicle in test medium (stock solution and final test solution(s) at different concentrations and in control(s)):

- Nominal values

Substance TM Concentration Solubilizer Tween 80
pos. Control 0.5 mg/L 100 mg/L
pos. Control 0.05 mg/L 100 mg/L
Test item: 31 mg/L 100 mg/L
Control: -- --
Vehicle: -- 100 mg/L

Test organisms (species):
Danio rerio (previous name: Brachydanio rerio)
Details on test organisms:
Weight: 0.24 +/- 0.03 g
Length: 3.2 +/- 0.2 cm
Date: 2007-10-31
Test type:
static
Water media type:
freshwater
Limit test:
no
Total exposure duration:
96 h
Post exposure observation period:
no
Test temperature:
23.8 +/- 0.4 °C
Details on test conditions:
10 fish per 4 L
Reference substance (positive control):
not specified
Key result
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
> 31 mg/L
Nominal / measured:
meas. (initial)
Conc. based on:
test mat.
Basis for effect:
mortality
Validity criteria fulfilled:
yes
Conclusions:
The LC50 of the test material exceeds 31 mg/L and is clearly above the limit of water solubility.
Executive summary:

The informtion for this endpoint study record was obtained from an experimental study. The OECD GLP criteria were met and the methods applied are fully compliant with OECD TG 203. The LC50 of the test material exceeds 31 mg/L and is clearly above the limit of water solubility.

Description of key information

GLP OECD 203 Assay: NOEC=31 mg/L (measured initial) with solubilizer

Key value for chemical safety assessment

LC50 for freshwater fish:
31 mg/L

Additional information

The LC50 of the test material exceeds 31 mg/L and is clearly above the limit of water solubility.