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EC number: 202-845-2
CAS number: 100-37-8
Since gonadal atrophy was noted in four of ten male and one of ten female rats on the preliminary examination of the Test High Level and the gonadal tissues of the twenty control animals were found to be within normal limits, additional sections of gonads from all survivors at termination (24 months) were prepared to resolve the question of possible drug toxicity. The additional study comprised tissues from twenty four (24) males and twenty seven (27) females in the control group, eighteen (18) males and twenty one (21) females in the Test Low Level group, seventeen (17) males and twelve (12) females in the Test Intermediate Level group, and five (5) males and eight (8) females in the Test High Level group. All sections of ovary in the additional study in all groups (test and control) were within the limits of expected histological appearance.
All additional sections of testis in the control and Test High Level groups were similarly normal. Mild to moderate atrophy of the testicular tubules, with decreased cellularity and reduced to absent spermatogenesis was present in three (3) males in the Low Test Level group and two (2) males in the Intermediate Test Level group.
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