Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 202-845-2 | CAS number: 100-37-8
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
DEAE was evaluated for dermal sensitization in 20 female Hartley guinea pigs by maximization test similar to OECD guideline 406 (Leung 1998; Val. 2). For induction, the animals were given intradermal injections into 2 sites each of clipped shoulder skin followed by a 48 h epicutaneous application 7 days later. Epicutanous challenge was performed by a 24 h patch at 14 days after induction to a previous untreated site. None of the animals treated with the test substance (0/20) exhibited skin responses. All 10 positive control animals challenged with DCNB showed a clear response.
In a second study the induction was made via intradermal injection of 10000 ppm and topical treatment with a 50000 ppm solution in olive oil (Nakamura 1994; Val. 2). Twenty-one days after the initial intradermal injection, 0,1 ml aliquots of various non-irritation concentrations of DEAE were applied in saline for challenge (0, 1250, 2500, 5000, 10000 ppm). Sensitisation was not observed in any of the DEAE-challenged animals.
In an older study ten guinea pigs were used and inducted with intradermal injections of 0.1% aqueous solutions every other day for a total of 10 doses (Pennwalt 1958; Val. 2). 14 days after the last application the animals were challenged with a single intradermal injection of a 0.1% aqueous solution. 24 hours after challenge injection the skin sensitization was evaluated. According to the authors, the test substance was not a sensitizer in this study. Zero out of 10 animals responded to DEAE.
Thus, taking all 3 studies into consideration, none of the 2 -diethylaminoethanol-induced animals showed signs of sensitization after challenge.
Migrated from Short description of key information:
not sensitising
Respiratory sensitisation
Endpoint conclusion
- Additional information:
- Migrated from Short description of key information:
no data available concerning respiratory sensitising potential
Justification for classification or non-classification
EU classification according to Annex I of Directive 67/548/EEC: none
EU classification according to EC/1272/2008 (CLP): none
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
