Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

DEAE was evaluated for dermal sensitization in 20 female Hartley guinea pigs by maximization test similar to OECD guideline 406 (Leung 1998; Val. 2). For induction, the animals were given intradermal injections into 2 sites each of clipped shoulder skin followed by a 48 h epicutaneous application 7 days later. Epicutanous challenge was performed by a 24 h patch at 14 days after induction to a previous untreated site. None of the animals treated with the test substance (0/20) exhibited skin responses. All 10 positive control animals challenged with DCNB showed a clear response.

In a second study the induction was made via intradermal injection of 10000 ppm and topical treatment with a 50000 ppm solution in olive oil (Nakamura 1994; Val. 2). Twenty-one days after the initial intradermal injection, 0,1 ml aliquots of various non-irritation concentrations of DEAE were applied in saline for challenge (0, 1250, 2500, 5000, 10000 ppm). Sensitisation was not observed in any of the DEAE-challenged animals.

In an older study ten guinea pigs were used and inducted with intradermal injections of 0.1% aqueous solutions every other day for a total of 10 doses (Pennwalt 1958; Val. 2). 14 days after the last application the animals were challenged with a single intradermal injection of a 0.1% aqueous solution. 24 hours after challenge injection the skin sensitization was evaluated. According to the authors, the test substance was not a sensitizer in this study. Zero out of 10 animals responded to DEAE.

Thus, taking all 3 studies into consideration, none of the 2 -diethylaminoethanol-induced animals showed signs of sensitization after challenge.

Migrated from Short description of key information:
not sensitising

Respiratory sensitisation

Endpoint conclusion
Additional information:
Migrated from Short description of key information:
no data available concerning respiratory sensitising potential

Justification for classification or non-classification

EU classification according to Annex I of Directive 67/548/EEC: none

EU classification according to EC/1272/2008 (CLP): none