2-diethylaminoethanol

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

17. Dec 1968 - 27. Dec 1968

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Scientifically valid study, but not according to current standards or GLP.

Data source

Reference

Reference 1

Reference Type:

study report

Title:

Unnamed

Year:

1969

Report date:

1969

Reference 2

Reference Type:

other: Translation of the original German study report XVIII/320

Title:

Unnamed

Year:

2002

Report date:

2002

Materials and methods

Principles of method if other than guideline:

BASF-Test: The study was conducted according to an internal BASF method which in principle is comparable to the OECD Guideline 401. A test group consisting of 10 animals/sex was treated by single gavage application with an aqueous solution of the test substance. The animals were observed for mortality and for clinical symptoms of toxicity. At the end of the observation period, the surviving animals were sacrificed for the purpose of necropsy; animals that died during the observations period also were subjected to necropsy.

GLP compliance:

no

Remarks:

GLP was not compulsory at the time the study was conducted

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

2-diethylaminoethanol

EC Number:

202-845-2

EC Name:

2-diethylaminoethanol

Cas Number:

100-37-8

Molecular formula:

C6H15NO

IUPAC Name:

2-(diethylamino)ethanol

Details on test material:

- Name of test material (as cited in study report): Diaethylaethanolamin
- Analytical purity: 99 %

Test animals

Species:

rat

Strain:

other: US-rats, not further specified

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Weight at study initiation: male: 204 g (mean); female: 167 g (mean)

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

water

Doses:

177, 708, 1106 and 1416 mg/kg bw (the original values were reported as 200, 800, 1250 and 1600 µL/kg bw and were converted using a density d=0.885 g/cm3)

No. of animals per sex per dose:

10

Control animals:

no

Details on study design:

- Duration of observation period following administration: 7 days
- Frequency of observations: daily
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

ca. 1 320 mg/kg bw

Remarks on result:

other: conversation in mg/kg bw based on the density: d=0.885 g/cm3

Mortality:

1416 mg/kg bw: 4 males and 9 females died within the first 24 hours; by 48 h one additional male died;
708 mg/kg bw: 1 male died on the 3rd day after application.

Clinical signs:

other: 708 mg/kg: immediately after application apathy and dyspnea; by the next day the animals were mostly without symptoms; 1106 mg/kg: immediately after application apathy and dyspnea; on the next day dyspnea and unkempt fur; 1416 mg/kg: immediately after

Gross pathology:

Hemorrhage into the gastro-intestinal tract was observed in the animals that died.
The animals that survivied to the end had no unusual findings except for chronic bronchitis in 2 animals of the 708 mg/kg bw dose group.

Any other information on results incl. tables

Mortality:

Dose (mg/kg bw)	Gender	Conc. %	1 h	24 h	48 h	day 7
1416	male	20	0	4	5	5
1416	female	20	0	9	9	9
1106	male	10	0	0	0	0
1106	female	10	0	0	0	0
708	male	8	0	0	0	1
708	female	8	0	0	0	0
177	male	2	0	0	0	0
177	female	2	0	0	0	0