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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1982
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1982
Report Date:
1982

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
GLP compliance:
not specified
Test type:
fixed dose procedure

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid: flakes

Test animals

Species:
rat
Strain:
not specified
Sex:
male
Details on test animals and environmental conditions:
The subcutaneous toxicity of Simmondsia Chinensis (Jojoba) Seed Wax was evaluated using 3 groups of 6-week-old male rats (10 rats/group)

Administration / exposure

Type of coverage:
other: subcutaneous
Vehicle:
unchanged (no vehicle)
Details on dermal exposure:
The 2 experimental groups received subcutaneous injections of the substance (1 ml/kg/bw) 6 days per week for 7 weeks
Duration of exposure:
7 weeks
Doses:
1 mL/kg/BW
No. of animals per sex per dose:
3 groups of 6-week-old male rats (10 rats/group)
Control animals:
yes, concurrent vehicle
Remarks:
Refined olive oil

Results and discussion

Effect levels
Key result
Sex:
male
Dose descriptor:
other: NOAEL
Effect level:
>= 1 mL/kg bw
Based on:
test mat.
Remarks on result:
no indication of skin irritation up to the relevant limit dose level
Mortality:
none
Clinical signs:
none
Other findings:
a slight increase in liver weight relative to the increase in body weight observed, no significant differences in body weight or organ weight between experimental and control groups, nor microscopic changes in the skin or in any of the other organs.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
Simmondsia Chinensis (Jojoba) Seed Wax is considered not harmful by dermal route.