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EC number: 209-013-8 | CAS number: 552-45-4
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Read across from structural analogue
- Justification for type of information:
- For "read across justification" please refer to section "additional information" in the endpoint summary.
- Reason / purpose for cross-reference:
- read-across source
- Transformation products:
- not measured
- Key result
- pH:
- 7
- Temp.:
- 25 °C
- DT50:
- 15 h
- Type:
- (pseudo-)first order (= half-life)
- Remarks on result:
- other: calculation based on results of Robertson & Scott (1961)
- Remarks:
- Mabey & Mill (1978)
- pH:
- 7
- Temp.:
- 15 °C
- Hydrolysis rate constant:
- 0 s-1
- DT50:
- ca. 53 h
- Type:
- (pseudo-)first order (= half-life)
- Remarks on result:
- other: linear temperature-dependence assumed
- Remarks:
- Robertson & Scott (1961)
- pH:
- 7
- Temp.:
- 20 °C
- Hydrolysis rate constant:
- 0 s-1
- DT50:
- ca. 27 h
- Type:
- (pseudo-)first order (= half-life)
- Remarks on result:
- other: linear temperature-dependence assumed
- Remarks:
- Robertson & Scott (1961)
- pH:
- 7
- Temp.:
- 30 °C
- Hydrolysis rate constant:
- 0 s-1
- DT50:
- ca. 8 h
- Type:
- (pseudo-)first order (= half-life)
- Remarks on result:
- other: linear temperature-dependence assumed
- Remarks:
- Robertson & Scott (1961)
- Endpoint:
- hydrolysis
- Type of information:
- other: collection of data
- Remarks:
- GDCh-Advisory Committee on Existing Chemicals of Environmental Relevance (BUA): BUA Report 188 (May 1996)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Principles of method if other than guideline:
- Data from colletion of data. Details not available.
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- Data from colletion of data. Details not available.
- Radiolabelling:
- not specified
- Analytical monitoring:
- not specified
- Details on sampling:
- Not specified
- Buffers:
- Not specified
- Estimation method (if used):
- Not specified
- Details on test conditions:
- Robertson & Scott (1961): 0.001 M KCl solution
- Number of replicates:
- Data from colletion of data. Details not available.
- Positive controls:
- not specified
- Negative controls:
- not specified
- Statistical methods:
- Not specified
- Preliminary study:
- Not specified
- Test performance:
- Not specified
- Transformation products:
- yes
- No.:
- #1
- No.:
- #2
- Key result
- pH:
- 7
- Temp.:
- 25 °C
- DT50:
- 15 h
- Type:
- (pseudo-)first order (= half-life)
- Remarks on result:
- other: calculation based on results of Robertson & Scott (1961)
- Remarks:
- Mabey & Mill (1978)
- pH:
- 7
- Temp.:
- 15 °C
- Hydrolysis rate constant:
- 0 s-1
- DT50:
- ca. 53 h
- Type:
- (pseudo-)first order (= half-life)
- Remarks on result:
- other: linear temperature-dependence assumed
- Remarks:
- Robertson & Scott (1961)
- pH:
- 7
- Temp.:
- 20 °C
- Hydrolysis rate constant:
- 0 s-1
- DT50:
- ca. 27 h
- Type:
- (pseudo-)first order (= half-life)
- Remarks on result:
- other: linear temperature-dependence assumed
- Remarks:
- Robertson & Scott (1961)
- pH:
- 7
- Temp.:
- 30 °C
- Hydrolysis rate constant:
- 0 s-1
- DT50:
- ca. 8 h
- Type:
- (pseudo-)first order (= half-life)
- Remarks on result:
- other: linear temperature-dependence assumed
- Remarks:
- Robertson & Scott (1961)
- Details on results:
- Not specified
- Results with reference substance:
- Not specified
- Validity criteria fulfilled:
- not applicable
Referenceopen allclose all
Description of key information
The half-life for hydrolysis of the test substance was determined to be 15 hours at 25°C and pH 7.
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 15 h
- at the temperature of:
- 25 °C
Additional information
No experimental data on hydrolysis are available for the substance itself. Therefore, the hydrolytical potential is assessed based on data available for the close structural analogue benzyl chloride (CAS 100-44-7). This analogue differs from the test substance only in that it has an additional methyl group in ortho-position.
The structural analogue benzyl chloride (CAS 100 -44 -7) was found to hydrolyze in aqueous solution to benzyl alcohol and hydrochloric acid, whereby the hydrolysis varies with temperature and test solution (GDCh, 1998). Based on thermodynamic data, the half-life of the structural analogue in natural waters was determined to be 15 hours at 25 °C and pH 7. Since the test substance (CAS 552-45-4) differs from the structural analogue benzyl chloride (CAS 100-44 -7) only in that it has a methyl group in ortho-position, the half life of the test substance is considered to be 15 hours at 25 °C.
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