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EC number: 232-800-2 | CAS number: 9025-57-4
The objective of this study was to assess the acute toxicity of Xylanase when administered as a single oral dose to six rats followed by an observation period of 14 days. The purpose of the study was to satisfy regulatory demands because the enzyme is used for production of food in China.
The study was conducted in accordance with the OECD Guideline No 423, “Acute Oral Toxicity – Acute Toxic Class method”. The design of the limit test was used. The test item was supplied as a brown liquid ready to use. The dose volume administered was 20.6 mL/kg body weight corresponding to 2102 mg/kg body weight, based on the Total Organic Solids (TOS) content of the test substance.
No mortality or clinical signs were observed after treatment and the overall body weight gain during the study was considered to be normal. The necropsy revealed no abnormalities.
In conclusion, no signs of toxicity were observed among the rats treated with a single oral dose of 2102 mg TOS/kg body weight, which was the highest possible dose at dose volume 20.6 mL/kg, using the undiluted test item.
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