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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1980
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Comparable to guideline study (OECD 404). Non GLP.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1980
Report date:
1980

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
Principles of method if other than guideline:
Method: according to Fed. Reg. 38 (187), §1500.41, p. 27029, 27-Sep-1973
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
3,4-dimethoxyphenylacetonitrile
EC Number:
202-225-1
EC Name:
3,4-dimethoxyphenylacetonitrile
Cas Number:
93-17-4
Molecular formula:
C10H11NO2
IUPAC Name:
3,4-dimethoxyphenylacetonitrile
Test material form:
solid
Details on test material:
Veratrylcyanid, PSN 78/834; no data on purity given in the report.

Test animals

Species:
rabbit
Strain:
Vienna White
Details on test animals or test system and environmental conditions:
- source: Gaukler
- number of animals: 2 males and 4 females
- mean body weights [kg] at application time: 2.8 (males) and 2.52 (females)

Test system

Type of coverage:
occlusive
Preparation of test site:
other: clipped
Vehicle:
water
Controls:
other: untreated skin of the animals
Amount / concentration applied:
- Concentration: 50 %
- amount: ca. 0.5 g
- area of application: 2.5 x 2.5 cm
Duration of treatment / exposure:
24 h
Observation period:
8 days
Number of animals:
6

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Basis:
other: mean animal #1-6
Time point:
other: 24/48/72 h
Score:
0.28
Max. score:
4
Reversibility:
fully reversible
Irritation parameter:
edema score
Basis:
other: mean animal #1-6
Time point:
other: 24/48/72 h
Score:
0
Max. score:
4
Reversibility:
fully reversible

Any other information on results incl. tables

Individual animal data:

Readings Animal Redness Edema
24 h 1 1 0
0 2 1 0
0 3 1 0
0 4 1 0
0 5 0 0
0 6 1 0
48 h 1 0 0
0 2 0 0
0 3 0 0
0 4 0 0
0 5 0 0
0 6 0 0
72 h 1 0 0
0 2 0 0
0 3 0 0
0 4 0 0
0 5 0 0
0 6 0 0
Mean 24-72h 1 0,33 0,00
0 2 0,33 0,00
0 3 0,33 0,00
0 4 0,33 0,00
0 5 0,00 0,00
0 6 0,33 0,00
Mean 24-72h mean #1-6 0,28 0,00

Grading: 0 - none, 1 - questionable, 2 - slight, 3 - strong, 4 - very strong.

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information
Conclusions:
Based on the results of this study, the test substance veratrylcyanid does not have to be classified according to Regulation (EU) 1272/2008.