Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 946-436-3 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Particle size distribution (Granulometry)
Administrative data
- Endpoint:
- particle size distribution (granulometry)
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study does not need to be conducted because the substance is marketed or used in a non solid or granular form
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
Reference
- Endpoint:
- appearance / physical state / colour
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 2015-07-24 to 2016-06-24
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- no guideline available
- GLP compliance:
- not specified
- Other quality assurance:
- other: ISO 14001
- Physical state at 20°C and 1013 hPa:
- solid
- Form:
- other: waxy solid
- Colour:
- White
- Substance type:
- organic
- Conclusions:
- Cyastat SN is an organic solid substance, appearing under the form of white waxy solid at ambient temperature and pressure.
- Executive summary:
The substance, Cyastat SN, was tested for several physico-chemical properties. In this context, the appearance of the sample was described, indicating that Cyastat SN is a white waxy solid substance
- Reason / purpose for cross-reference:
- reference to same study
Reference
- Endpoint:
- melting point/freezing point
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 2015-07-24 to January 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 102 (Melting point / Melting Range)
- Deviations:
- no
- GLP compliance:
- not specified
- Other quality assurance:
- other: ISO 14001
- Type of method:
- differential scanning calorimetry
- Melting / freezing pt.:
- 39 °C
- Decomposition:
- no
- Conclusions:
- The melting temperature of Cyastat SN was 39°C.
- Executive summary:
Melting point of Cyastat SN has been determined according to OECD test guideline 102. Using Differential Scanning Calorimetry (DSC), the melting temperature of the test substance was determined to be equal to 39°C
Melting pojnt / melting range of the test substance determined on 1st heat cycle.
Specimen No. |
Onset (Melting Point) (°C) |
Peak (°C) |
Endset (°C) |
Melting Range (°C) |
Enthalpy (joules/g) |
1 |
39.00 |
47.68 |
53.1 |
39 - 53 |
59.870 |
2 |
38.89 |
46.63 |
52.8 |
39 - 53 |
57.709 |
Specimen weights and appearance during DSC experiments.
Specimen No. |
Initial specimen wt (mg) |
Appearance |
1 |
4.6870 |
Both specimens were a sticky white waxy solid before and after experiment with no discoloration observed. |
2 |
7.6100 |
- Reason / purpose for cross-reference:
- reference to same study
Reference
- Endpoint:
- boiling point
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 2015-07-24 to Januaery 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 103 (Boiling Point)
- Deviations:
- no
- GLP compliance:
- not specified
- Other quality assurance:
- other: ISO 14001
- Type of method:
- differential scanning calorimetry
- Decomposition:
- yes
- Decomp. temp.:
- > 196 - < 220 °C
- Conclusions:
- The Cyastat SN decompose before boiling
- Executive summary:
Boiling Point has been determined according to OECD guideline 103. Using Differential scanning calorimetry (DSC), it was showed that the Cyastat SN decompose before boiling.
The test substance does not boil, instead it decomposes. Decomposition was confirmed by performing multiple DSC scans at different heating rates. The onset at 2.5°C/min is 195°C. Consequently, increasing the scan speed to 20°C/min delays the onset of decomposition to 220°C. Decomposition is a 2nd order reaction and is dependent upon the heating rate. Boiling point is a 1st order reaction independent of heating rate. Thus the different onset temperatures observed confirms that the thermal event is decomposition. The table below provides the onsets of decomposition at three different scan rates.
Onset of Decomposition for Test Substance.
Specimen No. |
Onset (°C) |
Heating Rate (°C/minute) |
1 |
196 |
2.5 |
2 |
196 |
2.5 |
3 |
211 |
10 |
4 |
211 |
10 |
5 |
221 |
20 |
6 |
218 |
20 |
Specimen weights and appearance during DSC experiments.
Specimen N° |
Initial specimen wt (mg) |
Post run appearance |
1 |
4.822 |
All of the specimens experienced a color change of white to brown. There was condensation of all specimens on top of the DSC pan lid through the pinhole confirming decomposition. |
2 |
4.719 |
|
3 |
5.001 |
|
4 |
4.914 |
|
5 |
4.558 |
|
6 |
5.067 |
- Reason / purpose for cross-reference:
- reference to same study
Reference
- Endpoint:
- density, other
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 2017-07-24 to january 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 109 (Density of Liquids and Solids)
- Deviations:
- no
- GLP compliance:
- not specified
- Other quality assurance:
- other: ISO14001
- Type of method:
- pycnometer method
- Type:
- density
- Density:
- 1.08 g/cm³
- Temp.:
- 23.4 °C
- Conclusions:
- The density of Cyastat SN was 1.09 g/cm3 at 23.4°C
- Executive summary:
Density of Cyastat SN has been determined according to OECD test guideline 103. Using a pycnometer method, the density of the test substance was determined to be 1.08 g/cm3 at 23.4 °C.
Summary of Density Results, specimen weights, and room temperature during analysis.
Test Substance Specimen No. |
Average true volume (n=10) (mL) |
Average Density (n=10) (g/mL) |
S.D. |
Initial specimen weight (g) |
Final sample weight (g) |
Temperature (°C) |
1 |
5.9307 |
1.0812 |
0.0003 |
6.4123 |
6.4123 |
23.4 |
2 |
5.8536 |
1.0810 |
0.0003 |
6.3277 |
6.3276 |
23.4 |
- Reason / purpose for cross-reference:
- reference to same study
Reference
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- no guideline followed
- Version / remarks:
- See principles of method if other than guideline
- Principles of method if other than guideline:
- The octanol water partitioning coefficient was estimated using the solubility of the test substance in the pure phases (n-octanol and water). This is because the test substance is a salt and surface active which means neither the shake-flask method (OECD 107) nor the HPLC method (OECD 117) are suitable to determine the log POW of the test substance
- GLP compliance:
- not specified
- Other quality assurance:
- other: ISO14001
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Analytical method:
- liquid chromatography
- Type:
- log Pow
- Partition coefficient:
- > 0.32 - < 1.75
- Temp.:
- 20 °C
- pH:
- 6.8
- Details on results:
- The test substance is more soluble in octanol than in water and there was no undissolved test substance in concentrations prepared for concentrations less than 40.5 weight %. Concentrations at 10, 20, 30, and 40 weight % were clear solutions. Therefore, only three supernatants were collected on concentrations higher than 40 weight %. The three initial concentrations whereby undissolved test substance was observed were prepared at 45, 50, and 55 weight %. The supernatants were collected after 24, 48, and 72 hours equilibrium and diluted with THF. The LC/CAD results showed 40.5, 40.7, and 40.3 weight % respectively.
- Conclusions:
- The log Kow was determined to be in the range of 0.32 -1.75 depending on the concentration of the substance.
- Executive summary:
Log Kow o the Cyastat SN was determined based on solubility of the test substance in water and in octanol. The solubility in Octanol and water were determinated by LC/CAD method.
- Reason / purpose for cross-reference:
- reference to same study
Reference
- Endpoint:
- vapour pressure
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 2015-07-24 to 2016-06-24
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 104 (Vapour Pressure Curve)
- Deviations:
- yes
- Remarks:
- a pan was used instead of a plate
- GLP compliance:
- not specified
- Other quality assurance:
- other: ISO 14001
- Type of method:
- effusion method: isothermal thermogravimetry
- Test no.:
- #1
- Temp.:
- 50 °C
- Vapour pressure:
- 0.163 Pa
- Test no.:
- #2
- Temp.:
- 60 °C
- Vapour pressure:
- 0.186 Pa
- Test no.:
- #3
- Temp.:
- 70 °C
- Vapour pressure:
- 0.21 Pa
- Test no.:
- #4
- Temp.:
- 80 °C
- Vapour pressure:
- 0.21 Pa
- Conclusions:
- The vapour pressure of Cyastat SN was determined to be equal to 0.16 Pa at 50°C.
- Executive summary:
Density of Cyastat SN has been determined according to OECD test guideline 104. Using TGA method, the vapour pressure of the test substance was determined to be 0.16 Pa at 50 °C.
The evaporation rate of the test substance was determined at 5 temperatures between 60 and 175°C. The equation in the plot above was used to calculate the vapor pressure. See results in Table 8.2. The calculated vapor pressure based on evaporation rates was plotted against temperature in order to derive the vapor pressure equation. The calculated vapor pressures were done in mm Hg because all calibration tables were done in this unit. After, the calculated vapor pressures for the test substance were converted to Pascal as per OECD Guideline.
Table 8.2. Experimental evaporation rates of test substance with calculated vapor pressure.
Temp. (°C) |
Evaporation Rate (µg/min) |
log Evaporation Rate (µg/min) |
Temp. (1/K) |
Log Vapor Pressure (mmHg) |
Calculated Vapor Pressure (mm Hg) |
Calculated Vapor Pressure (Pascal) |
60 |
0.0684 |
-1.164943898 |
0.003002 |
-2.855596556 |
0.001394 |
0.1859 |
80 |
0.0875 |
-1.057991947 |
0.002832 |
-2.745346474 |
0.001797 |
0.2396 |
50 |
0.0601 |
-1.221125528 |
0.003095 |
-2.913510686 |
0.001220 |
0.1627 |
70 |
0.0770 |
-1.113509275 |
0.002914 |
-2.802575817 |
0.001576 |
0.2101 |
- Reason / purpose for cross-reference:
- reference to same study
Reference
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- GLP compliance:
- not specified
- Other quality assurance:
- other: ISO 14001
- Type of method:
- flask method
- Water solubility:
- < 0.5 other: w/%
- Conc. based on:
- test mat.
- Incubation duration:
- 24 h
- Temp.:
- 20 °C
- pH:
- 6.8
- Conclusions:
- The water solubility of Caystat SN was estimated to be less than 0.5%/w
- Executive summary:
Water solubility of Caystat SN has been determined according to OECD test guideline 105. Using LC/CAD, the water solubility of the test substance was determined to be less than 0.5%/w at 20 °C.
Water solubility results done by LC/CAD contingent on initial concentrations at 20 °C
*Initial concentration (Weight %) |
Solubility (Weight %) |
||||
24 hours |
48 hours |
72 hours |
Mean |
Maximum Difference **(M.D) |
|
1.0 |
0.73 |
0.70 |
0.72 |
0.717 |
4.19 |
4.0 |
2.57 |
2.54 |
2.61 |
2.57 |
2.72 |
16.0 |
10.54 |
10.44 |
10.76 |
10.6 |
3.02 |
22.2 |
13.78 |
13.56 |
13.68 |
13.7 |
1.61 |
39.0 |
19.69 |
19.91 |
18.80 |
19.5 |
5.70 |
*This is the initial concentration of the test substance in water. At all of these concentrations there was undissolved test substance. The pH of all collected supernatants was 6.8.
**We calculate the M.D. as follows:
M.D. = ((highest value - lowest value) / mean value) x 100
where: mean value is the mean of the highest and lowest value
According to OECD 105, the maximum difference should be <15% “If the concentrations measured in at least the two last vessels do not differ by more than 15%, the test is satisfactory.” However, this statement is valid for very pure test substances consisting of single components. This test substance consists of multiple components varying in water solubility. The results are not increasing with additional equilibrium time, thus analysis is satisfactory.
- Reason / purpose for cross-reference:
- reference to same study
Reference
- Endpoint:
- surface tension
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 2015-07-24 to January 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 115 (Surface Tension of Aqueous Solutions)
- GLP compliance:
- not specified
- Other quality assurance:
- other: ISO 14001
- Type of method:
- ring method
- Specific details on test material used for the study:
- A 1 g/L test solution was prepared of the test substance in distilled water. Two aliquots were poured into test vessels immediately after preparation.
A 1 g/L test solution was used after determining that solubility of the test substance in water exceeds 0.3 wt%. The test solution is water clear and less than 200 mPa s (200 centipoise). - Surface tension:
- 42.7 mN/m
- Temp.:
- 20 °C
- Conc.:
- 1 g/L
- Conclusions:
- The surface tension of Cyastat SN was 42.7 mN/m at 20°C
- Executive summary:
Surface tension of Cyastat SN has been determined according to OECD test guideline 115. Using a Kruss digital Tensiometer K-10 and Dunouy ring method, the surface tension of the test substance was determined to be equal to 42.7 mN/m at 20°C
Surface Tensions of 1 g/L Test Substance in Water at 20°C.
Surface Tension of test solution #1 (mN/m) |
Surface Tension of test solution #2 (mN/m) |
Equilibrium Time after pouring into test vessel |
42.7 |
42.7 |
20 seconds |
42.6 |
42.8 |
90 seconds |
42.7 |
42.7 |
180 seconds |
42.8 |
42.7 |
300 seconds |
The surface tension of the above test solution does not have any dependence on time.
Data source
Materials and methods
Results and discussion
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.