Registration Dossier
Registration Dossier
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EC number: 208-293-9 | CAS number: 520-45-6
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Reported in 1950
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Dehydroacetic acid (DHA): 1. Acute and chronic toxicity
- Author:
- Spencer HC, Rowe VK & McCollister DD
- Year:
- 1 950
- Bibliographic source:
- J. Pharmacol. Exp. Therap., 99; 57-68
Materials and methods
- Principles of method if other than guideline:
- Method was described as essentially like that of Draize et al., (1944) J. Pharmacol. Exp. Therap. 82; 377. Cited in Principles and Methods of Toxicology, 5th Edition; ed. A. Wallace-Hayes, 2008.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 3-acetyl-6-methyl-2H-pyran-2,4(3H)-dione
- EC Number:
- 208-293-9
- EC Name:
- 3-acetyl-6-methyl-2H-pyran-2,4(3H)-dione
- Cas Number:
- 520-45-6
- Molecular formula:
- C8H8O4
- IUPAC Name:
- 3-acetyl-6-methyl-2H-pyran-2,4(3H)-dione
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- other: Greaseless base - "Neobase".
- Details on dermal exposure:
- After application of the dosage, the site was occluded by bandages for 24 hours after which time they were removed and the site washed with soap and water.
- Duration of exposure:
- 24 hours
- Doses:
- 1000, 3000 or 5000 mg/kg bw
- No. of animals per sex per dose:
- 2
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- approximate LD50
- Effect level:
- > 3 000 - < 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- One of the two rabbits treated at 5000 mg/kg bw died
Applicant's summary and conclusion
- Interpretation of results:
- other: CLP/EU GHS criteria not met, no classification required according to Regulation(EC) No. 1272/2008
- Conclusions:
- No rabbits died at 1000 or 3000 mg/kg bw. The LD50 was considered to be greater than 3000 mg/kg bw
- Executive summary:
Rabbits were treated dermally for 24 hours with dihydroacetic acid at dosages between 1000 and 5000 mg/kg bw. There were no deaths at 1000 or 3000 mg/kg bw. The LD50 was considered to be greater than 3000 mg/kg bw.
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