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EC number: 211-317-0
CAS number: 638-07-3
dose toxicity (90 d, feeding)
feeding study was carried out according to OECD Guideline 409 on Wistar
rats (l0 anirnals/sex/group
over a test period of 90 days. The appropriate dose levels were
determined in 14 -d range finding study. The dose levels in the main
study were 0, 0.0085, 0.0847 and 0.8469 g/kg f'eed, equal to
cornpound intake of 0, 0.57, 5.66 and 56.06 mg/kg/d for males and 0,
0.64, 6.24 and 64.98 mg/kg/d for females. There was no mortality
observed during the study. Clinical signs included symptoms of
depression, reduction in activity and reduced food consumption were
observed in mid sand high dose groups. Body weights, food consumption
and food efficiency were statistically decreased in mid and high dose
groups mainly in both sexes starting from week 3 of the dosing period. A
number of changes were noted in blood parameters of the mid and high
dose animals. These findings included decrease in blood cell counts,
increase in hemtocrit values, decrease in lymphocytes, decrease of
creatinine concentrations etc. Changes on kidney-to-body-weight ratios
and brain-to-body-weight ratios were seen in mid and/or high dose groups
on females. Histopathological examination showed a number of effects in
some animals of mid and high dose groups, such as large number of
inflammatory cells in rat epididymis.
Based on these results, the NOAEL
(No-Observed-Adverse-Effect-Level) was 0.57 mg/kg/d for males and 0.64
mg/kg/d for females.
Based on the results of the study, the test
item needs to be classified as follows:
Acute toxicity cat.3; oral - H 301: Toxic if
Acute toxicity cat.2; dermal - H 310: Fatal
in contact with skin
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