Registration Dossier

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
other information
Study period:
1981
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Inhalation risk test in accordance to Smyth et al. (1962). Study was performed prior to the implementation of GLP and OECD Guidelines.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1981
Report Date:
1981

Materials and methods

GLP compliance:
no
Remarks:
test predated GLP
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent
Details on test material:
Name of test material:
Methoxyacetic acid

Impurities (identity and concentrations):
appr. 0.2 % formic acid
max. 0.5 % water
max. 0.1 % formaldehyde
< 0.1 % glycolic acid
< 0.1 % oxalic acid
< 0.5 % varied ester
< 0.001 % N

Test animals

Species:
rat
Strain:
not specified
Sex:
male/female

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
whole body
Vehicle:
other: unchanged (no vehicle)
Details on inhalation exposure:
Vapor-ladened air: 200 L air/h passing a product layer (5 cm) to create a vapor-air mixture.
Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
ca. 7 h
Concentrations:
Concentrated vapor inhalation (at 20 °C)
No. of animals per sex per dose:
12
Control animals:
no
Details on study design:
Duration of observation period: 14 days

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
other: mortality
Exp. duration:
7 h
Remarks on result:
other: No animal died during/after incubation
Mortality:
All animals survived.
Clinical signs:
other: Closing of the eyes, snout-wiping, rhinitis
Gross pathology:
Organs without findings - no macroscopic effects.

Applicant's summary and conclusion

Executive summary:
The inhalation toxicity of methoxyacetic acid was studied in a inhalation risk test (BASF, 1981). This involved passing 200 I air/hour through a 5 cm deep layer of methoxyacetic acid at 20 °C. Twelve rats were exposed to this mixture for 7 hours. Observed symptoms of toxicity included closing of the eyes, snout- wiping and rhinitis. No deaths occurred either during exposure or during the 14 -day observation period. Autopsy revealed no macroscopic findings.