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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Short-term toxicity to fish

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
short-term toxicity to fish
Type of information:
(Q)SAR
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Result based on an internationally accepted QSAR tool.
Justification for type of information:
1. SOFTWARE: OECD QSAR TOOLBOX
2. MODEL (incl. version number): ECOSAR v1.1 Class-specific Estimations
3. SMILES OR OTHER IDENTIFIERS USED AS INPUT FOR THE MODEL: O=C(OCCCCC[CC]CC]CCCCCCC)C(O)C
4. SCIENTIFIC VALIDITY OF THE (Q)SAR MODEL
- Defined endpoint: Fish - 96-hr - LC50
- Unambiguous algorithm: not applicable
- Defined domain of applicability: not applicable
- Class Specific LogKow Cut-Offs:
+ Esters: Maximum LogKow: 5.0 (Fish 96-hr LC50; Daphnid LC50, Mysid LC50), Maximum LogKow: 6.0 (Fish 14-day LC50);
+ Baseline Toxicity SAR Limitations: Maximum LogKow: 5.0 (Fish 96-hr LC50; Daphnid LC50).
Principles of method if other than guideline:
ECOSAR (Ecological Structure Activity Relationships) predicts the potential toxicity of industrial chemicals to organisms living in the water body to which the chemicals are discharged.
GLP compliance:
no
Analytical monitoring:
not required
Vehicle:
no
Test organisms (species):
other: Fish, the aquatic organisms are surrogates for the aquatic food web.
Test type:
not specified
Water media type:
freshwater
Total exposure duration:
96 h
Remarks on exposure duration:
h
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
0.261 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Remarks:
n-tetradecyl lactate
Basis for effect:
mortality (fish)
Remarks on result:
other: ECOSAR Class: esters
Key result
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
0.11 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Remarks:
n-tetradecyl lactate
Basis for effect:
mortality (fish)
Remarks on result:
other: Neutral Organic SAR (Baseline Toxicity)
Sublethal observations / clinical signs:

--------------------------------------

ECOSAR v1.1 Class-specific Estimations

--------------------------------------

n-tetradecyl lactate:

                                                                   Predicted

ECOSAR Class Esters       Organism           Duration End Pt  mg/L (ppm)

=========================== ================== ======== ======  

Esters                     : Fish               96-hr    LC50       0.261

Esters                     : Fish (SW)        96-hr    LC50       0.316

=========================== ================== ======== ====== 

Neutral Organic SAR       : Fish            96-hr    LC50       0.110

 

------------------------------

Class Specific LogKow Cut-Offs

------------------------------

If the log Kow of the chemical is greater than the endpoint specific cut-offs

presented below, then no effects at saturation are expected for those endpoints.

 

Esters:

------

Maximum LogKow: 5.0 (Fish 96-hr LC50; Daphnid LC50, Mysid LC50)

Maximum LogKow: 6.0 (Fish 14-day LC50; Earthworm LC50)

Maximum LogKow: 6.4 (Green Algae EC50)

Maximum LogKow: 8.0 (ChV)

 

Baseline Toxicity SAR Limitations:

---------------------------------

Maximum LogKow: 5.0 (Fish 96-hr LC50; Daphnid LC50)

Description of key information

Value calculated based on QSAR estimated individual LC50 values for the C14 -alkyl lactate ester being the main constituent.

Key value for chemical safety assessment

Fresh water fish

Fresh water fish
Effect concentration:
0.26 mg/L

Marine water fish

Marine water fish
Effect concentration:
0.32

Additional information