Registration Dossier
Registration Dossier
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EC number: 278-169-7 | CAS number: 75277-39-3
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- from 2015-10-19 to 2015-12-03
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- flask method
- Key result
- Water solubility:
- ca. 758.7 g/L
- Conc. based on:
- test mat.
- Loading of aqueous phase:
- 2 500 g/L
- Incubation duration:
- >= 2 - <= 6 d
- Temp.:
- 20 °C
- pH:
- ca. 11
- Water solubility:
- ca. 729.9 g/L
- Conc. based on:
- test mat.
- Loading of aqueous phase:
- 2 500 g/L
- Incubation duration:
- >= 2 - <= 6 d
- Temp.:
- 10 °C
- pH:
- ca. 10.9
- Conclusions:
- The mean water solubility was determined as 758.7 g/L at 20 °C.
- Executive summary:
The water solubility of the test item was determined in an experimental study under GLP conditions according to OECD Test Guideline 105 and EU Method A.6 using the flask method. The concentration was determined by a validated HPLC. The mean water solubility was determined at 20 °C as 758.7 g/L and at 10 °C as 729.9 g/L. The mean pH of the solutions was 11.0 and 10.9, respectively.
Reference
The mean water solubility (3 replicates on three days) was determined at 10 °C as 729.9 g/L at a pH of 10.9.
Water solubility at 10 °C:
Equilibration time | measurement 1 | measurement 2 | measurement 3 | mean |
Day 2 | 731.3 | 732.5 | 733.8 | 732.5 |
Day 3 | 724.4 | 727.0 | 727.5 | 726.3 |
Day 6 | 730.1 | 729.2 | 733.4 | 730.9 |
overall mean | 729.9 | |||
overall standard deviation | 3.17 | |||
The mean water solubility (3 replicates on three days) was determined at 20 °C as 758.7 g/L at a pH of 11.0.
Water solubility at 20 °C:
Equilibration time | measurement 1 | measurement 2 | measurement 3 | mean |
Day 2 | 763.4 | 760.7 | 758.4 | 760.8 |
Day 3 | 760.8 | 755.8 | 756.8 | 757.8 |
Day 6 | 761.8 | 756.3 | 754.3 | 757.5 |
overall mean | 758.7 | |||
overall standard deviation | 3.12 | |||
Description of key information
The mean water solubility was determined as 758.7 g/L at 20 °C (reference 4.8-1).
Key value for chemical safety assessment
- Water solubility:
- 758.7 g/L
- at the temperature of:
- 20 °C
Additional information
The water solubility of the test item was determined in an experimental study under GLP conditions according to OECD Test Guideline 105 and EU Method A.6 using the flask method. The concentration was determined by a validated HPLC. The mean water solubility was determined at 20 °C as 758.7 g/L and at 10 °C as 729.9 g/L. The mean pH of the solutions was 11.0 and 10.9, respectively.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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