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EC number: 205-788-1
CAS number: 151-21-3
The PBT assessment for CAS 151-21-3 is based on the criteria set
out in the "Guidance on information requirements and chemical safety
assessment, Chapter R.11: PBT Assessment" (ECHA, 2008).
Persistence (P) Assessment:
A substance is not considered to be persistent if it can be
demonstrated that it has potential to degrade (via photolysis,
hydrolysis and/or biodegradation). Several studies using standardized
test guidelines could demonstrate the ready biodegradability of the
substance (95% after 28 days based on CO2 evolution, OECD 301
B). Therefore, CAS 151-21-3 does not meet the Persistent (P) or very
Persistent (vP) criteria.
Bioaccumulation (B) Assessment:
The value of log Pow at 20 ºC is ≤ -2.03. Available data indicate
that CAS 151-21-3 has a very low potential for bioconcentration and the
substance will not accumulate to significant levels in the aquatic
environment. Therefore, CAS 151-21-3 does not meet the Bioaccumulative
(B) or very Bioaccumulative (vB) criteria.
Toxicity (T) Assessment:
According to Annex XIII of REACH Regulation (EC) No 1907/2006, a
substance is considered to be toxic in terms of PBT criteria if
long-term NOEC values for aquatic organisms are lower than 0.01 mg/L.
The NOEC value based on chronic experimental data on daphnids was 0.88
mg/L. This value exceeds the toxicity criterion and therefore, CAS
151-21-3 is not considered as a toxic substance regarding
Human Health Toxicity:
Carcinogenicity: the available data on CAS 151-21-3 do not warrant
classification for carcinogenicity under Directive 67/548/EEC or GHS/CLP.
Mutagenicity: the available data indicate that CAS 151-21-3 is not
genotoxic or mutagenic and do not warrant classification for
carcinogenicity under Directive 67/548/EEC or GHS/CLP.
Reproductive Toxicity: there is no evidence that CAS 151-21-3
causes reproductive or developmental toxicity. The available data
indicate that members of the alkyl sulfate category are not toxic to
reproduction and do not warrant classification under Directive
67/548/EEC or GHS/CLP.
Chronic toxicity: due to the results of the relevant mammalian
toxicity studies CAS 151-21-3 is not classified as Xn, R48 or STOT RE.
The substance is considered not to be PBT or vPvB on the basis of
the provided relevant data.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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