Registration Dossier
Registration Dossier
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EC number: 609-330-5 | CAS number: 370865-89-7
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 012
- Report date:
- 2012
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 431 (In Vitro Skin Corrosion: Human Skin Model Test)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 439 (In Vitro Skin Irritation: Reconstructed Human Epidermis Test Method)
- GLP compliance:
- yes
Test material
- Reference substance name:
- 3-ethyl-1-methyl-1H-Imidazolium salt with N-cyanocyanamide (1:1)
- EC Number:
- 609-330-5
- Cas Number:
- 370865-89-7
- Molecular formula:
- C6 H11 N2 .C2 N3
- IUPAC Name:
- 3-ethyl-1-methyl-1H-Imidazolium salt with N-cyanocyanamide (1:1)
Constituent 1
- Specific details on test material used for the study:
- - Name of the test substance (as cited in the study report): EMIM Dicyanamid
- Purity: 97.4g / 100 g
- pH value: ca. 5 (undiluted test substance)
In vitro test system
- Test system:
- human skin model
- Source species:
- human
- Amount/concentration applied:
- 30 µL (irritation test); 50 µL (corrosion test)
- Duration of treatment / exposure:
- - Irritation test: 1 hour followed by a 42-hours post-incubation period
- Corrosion test: 3 minutes and 1 hour, respectively - Number of replicates:
- - Irritation test: 3 tissues
- Corrosion test: 2 tissues
Test system
- Vehicle:
- unchanged (no vehicle)
Results and discussion
In vitro
Resultsopen allclose all
- Irritation / corrosion parameter:
- % tissue viability
- Remarks:
- mean
- Run / experiment:
- 1 h exposure, 42 h post-incubation (Irritation test)
- Value:
- 102
- Negative controls validity:
- valid
- Remarks:
- PBS
- Positive controls validity:
- valid
- Remarks:
- SDS
- Remarks on result:
- no indication of irritation
- Irritation / corrosion parameter:
- % tissue viability
- Remarks:
- mean
- Run / experiment:
- 3 min exposure (Corrosion test)
- Value:
- 88
- Negative controls validity:
- valid
- Remarks:
- H2O
- Positive controls validity:
- valid
- Remarks:
- KOH
- Remarks on result:
- no indication of irritation
- Irritation / corrosion parameter:
- % tissue viability
- Remarks:
- mean
- Run / experiment:
- 1 h exposure (Corrosion test)
- Value:
- 73
- Negative controls validity:
- valid
- Remarks:
- H2O
- Positive controls validity:
- valid
- Remarks:
- KOH
- Remarks on result:
- no indication of irritation
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
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