Registration Dossier
Registration Dossier
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EC number: 233-433-0 | CAS number: 10163-15-2
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- no data
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Meets generally accepted scientific standards with acceptable restrictions.
Data source
Reference
- Reference Type:
- publication
- Title:
- Preliminary studies of the caries inhibiting potential and acute toxicity of sodium monofluorophosphate
- Author:
- Shourie KL, Hein JW & Hodge HC
- Year:
- 1 950
- Bibliographic source:
- J. D. Res. 29():529
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: no data
- Deviations:
- not specified
- Principles of method if other than guideline:
- One hundred and five albino rats were given graded doses from 74 mg/ kg to 465 mg/ kg of sodium monoflurophosphate as a 5% aqueous solution. The route of administration was intraperitoneal injection, the number of animals dead in 24 hours was used to calculate the LD50.
- GLP compliance:
- not specified
- Limit test:
- yes
Test material
- Reference substance name:
- Disodium fluorophosphate
- EC Number:
- 233-433-0
- EC Name:
- Disodium fluorophosphate
- Cas Number:
- 10163-15-2
- Molecular formula:
- FH2O3P.2Na
- IUPAC Name:
- disodium fluorophosphate
- Details on test material:
- - Name of test material (as cited in study report): sodium monofluorophosphate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 200-300 grams
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- water
- Details on exposure:
- no data
- Doses:
- Graded doses from 74 mg/ kg to 465 mg/ kg of sodium monoflurophosphate as a 5% aqueous solution.
- No. of animals per sex per dose:
- 105 rats were divided into 13 groups of five to ten animals.
- Control animals:
- not specified
- Details on study design:
- The number of animals dead within a 24 h observation period were used to calculate the LD50 of the compound
- Statistics:
- From the number of animals dead in 24 h the LD50 was calculated by use of the Winthrop logarithmic-probit graph paper.
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 220 mg/kg bw
- Remarks on result:
- other: ± 32 mg/ kg standard error
- Mortality:
- On the basis of Fluoride content alone the LD50 is 29 mg/ kg
- Clinical signs:
- No data.
- Body weight:
- No data.
- Gross pathology:
- No data.
- Other findings:
- No data.
Any other information on results incl. tables
No data.
Applicant's summary and conclusion
- Conclusions:
- The LD50 of sodium monofluorophosphate was 220 ± 32 mg/ kg bodyweight in rats weighing 200 to 300 grams.
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