Registration Dossier
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EC number: 272-695-0 | CAS number: 68909-18-2
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
A specific investigation of the toxicokinetics of the substance is not required as conclusions regarding likely toxicokinetic behaviour can be made by consideration of the chemical structure and by read-across to structurally related substances. The substance itself is a complex mixture of structurally-related compounds and, as such, would be difficult to investigate in a study of toxicokinetics.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
Additional information
A specific investigation of the toxicokinetics of the substance is not required as conclusions regarding likely toxicokinetic behaviour can be made by consideration of the chemical structure and by read-across to structurally related substances. The substance itself is a complex mixture of structurally-related compounds and, as such, would be difficult to investigate in a study of toxicokinetics.
Absorption
Published summaries of the evaluation of the related quaternary ammonium compounds didecyldimethylammonium chloride (DDAC) and alkyldimethyl benzyl ammonium chloride (ADBAC) are available and these indicate oral absorption of <2.5% and dermal penetration of 0.5%. No data are available for the extent absorption following inhalation exposure; however this is again considered unlikely to be significant. A WHO evaluation of quaternary ammonium compounds also notes poor absortpion following oral exposure.
Distribution
Systemic distribution of the very limited proportion of systemically absorbed substance is likely to be rapid due to its water soluble nature.
Metabolism
A published Canadian review of the toxicity of the quaternary ammonium compound didecyldimethylammonium chloride (DDAC) reports some oxidative metabolism of the decyl sidechain, but no molecular cleavage by N-dealkylation.
Excretion
Excretion of the very limited proportion of systemically absorbed substance is likely to be rapid and bioaccumulation is not predicted based on its physicochemical properties (log Pow).
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