Registration Dossier
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EC number: 272-695-0 | CAS number: 68909-18-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
No specific data on the toxicokinetics of MK92K are available. The likely toxicokinetic properties of the substance are addressed using theoretical considerations and by read-across from structurally similar substances: 1-(phenylmethyl)-alkyl pyridinium chloride derivatives.
No toxicokinetic data are available for these substances, however the data on related quaternary ammonium compounds are summarised by the WHO (1998), EPA (2006) and in a Canadian review (Henderson, 1992).
Absorption
Significant absorption of quaternary ammonium compounds is unlikely due to their highly ionic nature. WHO (1998) report the oral absorption of quaternary ammonium compounds in general to be poor. A published Canadian review of the toxicity of the quaternary ammonium compounddidecyldimethylammonium chloride (DDAC) notes experiments in rats in which up to 99% of orally administered radioactivity was recovered in the faeces and less than 2.5% in the urine (Henderson, 1992). The published US EPA summary of the toxicity of alkyldimethyl benzyl ammonium chloride (ADBAC) also reports that the majority (up to 98%) of administered radioactivity is eliminated in the faeces, with limited (5-8%) urinary excretion (EPA, 2006).
The dermal absorption of quaternary ammonium compounds is likely to be low based on the chemical structure, ionic nature, molecular weight and lack of lipophilicity of the substance. Absorption of this group of substances through skin is also indicated to be very low based on an absence of reports of systemic effects following dermal exposure (WHO, 1998). However it is noted that the substance is corrosive, therefore it is possible that systemic absorption may occur following significant accidental dermal exposures resulting in skin burns, where the normal barrier integrity of the skin is compromised. Buistet al(2007) report very low dermal penetration (0.5%) for the quaternary ammonium compound didecyldimethylammonium chloride (DDAC) in human skinin vitroover a 48-hour period.
No data are available for absorption following inhalation exposure, however it is considered unlikely that absorption by his route of exposure would be significant. Although not relevant to the human risk assessment, the WHO document notes that the systemic absorption of quaternary ammonium compounds following parenteral administration is ‘possible’.
Distribution
No data on distribution are available. However given the water solubility of the substance, it is likely to be widely distributed via the circulation if absorbed.
Metabolism
No data are available for the substance; however significant metabolism is not predicted given the likely poor systemic absorption. A published Canadian review of the toxicity of the quaternary ammonium compounddidecyldimethylammonium chloride (DDAC) reports some oxidative metabolism of the decyl sidechain, but no molecular cleavage by N-dealkylation (Henderson, (1992).
Excretion
Data indicate that quaternary ammonium compounds are largely excreted in the faeces (WHO, 1998; Henderson, 1992). The poor absorption and chemical nature of the substance (specifically the lack of lipophilicity) indicate that substance MK92K has no potential for bioaccumulation potential.
WHO (1998). QUATERNARY AMMONIUM COMPOUNDS. International Programme on Chemical Safety (IPCS Poisons Information Monograph G022 (Group PIM).
Buist HE, de Heer C, van Burgsteden JA & Van der Sandt JJ (2007). Dermatokinetics of didecyldimethylammonium chloride and the influence of some commercial biocidal formulations on its dermal absorption in vitro.
EPA (2006). Toxicology Disciplinary Chapter for the Re-Registration Eligibility Decision (RED) Risk Assessment of alkyldimethyl benzyl ammonium chloride (ADBAC).
Henderson ND (1992). A review of the environmental impact and toxic effects of DDAC. Environmental Protection Division, BC Environment.
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