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Long-term toxicity to aquatic invertebrates

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Two studies are now available that assess the short term (acute) toxicity of MK92K to invertebrates. A study was performed using Acartia Tonsa which is a marine species. There was no media analysis conducted, primarily due to the complex nature of the test compound. The 48h EC50 was 2.85mg/L. A second study has been performed using the fresh water invertebrate, Daphnia Magna. Verification of MK92K in the test media was performed using TOC analysis. This is not a specific analysis method but does nevertheless confirm the presence and concentration in solution. The result of this test (48h EC50 was 3.10 mg/L) is consistent with the result of the original test on the marine invertebrate and confirms that invertebrates are not the most sensitive aquatic species. In an algal growth inhibition test, the 72h ErC50 for MK92K was 0.47 mg/L, which is an order of magnitude lower than the acute daphnia endpoint.  

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