Decyl acetate

Vapour pressure

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

vapour pressure

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 104 (Vapour Pressure Curve)

Version / remarks:

1995

Principles of method if other than guideline:

The test substance is used as the stationary liquid phase in a gas-liquid chromatographic column. A suitable sample compound, the "probe", is repeatedly injected into the gas chromatograph and the net retention volume is carefully measured. The vapor pressure is determined at three to six temperatures in the interval 25-45°C by a gas chromatographic method suitable for accurate measurements of the low vapor pressures at biologically relevant temperatures.

GLP compliance:

no

Type of method:

gas saturation method

Temp.:

30.4 °C

Vapour pressure:

3.8 Pa

Key result

Temp.:

25.9 °C

Vapour pressure:

2.48 Pa

Temp. (°C)	VP (Pa)
25.9	2.48 +/- 0.01
26.1	2.52 +/- 0.04
30.4	3.80 +/- 0.05
34.8	5.66 +/- 0.03
39.4	8.86 +/- 0.03
39.5	8.70 +/- 0.11

Conclusions:

The vapour pressure was determined to be 2.48 Pa at 25.9°C and 3.80 Pa at 30.4°C.

Executive summary:

In the current study the vapour pressure of the test item was determined through gas chromatography. No OECD TG or EU method was used, but the method is similar to that described as the "gas saturation method" in OECD 104. The study was not according to GLP.

The vapor pressure is determined at six temperatures in the interval 25-45°C by a gas chromatographic method suitable for accurate measurements of the low vapor pressures at biologically relevant temperatures.

The vapour pressure was determined to be 2.48 Pa at 25.9°C and 3.80 Pa at 30.4°C.

Reference 2

Endpoint:

vapour pressure

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Study according to a method specifically developed for substances present in insect pheromones.

Principles of method if other than guideline:

The gas chromatography is an alternative method for measuring vapour pressures, with the advantage of speed, solute sample size, purity and stability requirements. Using the GC to determine the vapour pressure of compounds related to the retention time at different temperature.

GLP compliance:

no

Type of method:

other: gas chromatography retention data

Temp.:

25 °C

Vapour pressure:

2.25 Pa

Remarks on result:

other: calculated based on retention time

Application of equation

ln P_L= a + b*N

for decyl acetate results in a calculated vapour pressure of 2.25 Pa at 25°C.

Conclusions:

The vapour pressure was determined to be 2.25 Pa at 25 °C

Executive summary:

In the current study the vapour pressure of the test item was determined through gas chromatography. No OECD TG or EU method was used and the study was not according to GLP.

Samples were analysed on a Hewlett-Packard HP 5880 chromatograph equipped with a flame ioniza tion detector and a 2-m fused-silica capillary column with splitless injection. Chromatography was carried out isothermally at 10°C intervals from 90 to 140°C with a hydrogen flow-rate of 10 mL/min. n-C18 and n-C20 hydrocarbons were used as reference standards. Retention times were determined using an HP 3396A integrator, and these were used to calculate the vapour pressure.

The extrapolation of an equation related to the vapour pressure and the retention has been developed as following:

ln P_L= a + b*N

This equation has been applied to determine the vapour pressure of the test substance to be 2.25 Pa at 25°C.

Description of key information

Two studies are available in which the vapour pressure of the test substance has been determined.

The first study by Olson (1983) is a study that uses the principles of the gas saturation method by means of a gas chromatographic determination of the amount of material transported by a known amount of carrier gas.

The vapor pressure is determined at six temperatures in the interval 25-45°C, and was found to be 2.48 Pa at 25.9°C and 3.80 Pa at 30.4°C.

The second study by Koutek (1992) is based on a correlation between a substance's vapour pressure and its retention time in gas chromatography. The vapour pressure of decyl acetate was calculated by means of a linear regression equation, and was found to be 2.25 Pa at 25°C.

The available information is used in a weight-of-evidence approach. As the method by Olson determines the vapour pressure experimentally rather than by means of a calculation, the result obtained by Olson is taken as the key value.

Key value for chemical safety assessment

Vapour pressure:

2.48 Pa

at the temperature of:

25.9 °C