Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

Currently viewing:

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from Publication

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
TOXICITY OF ISONICOTINIC ACID
Author:
G. V. Tsarichenko, V. I. Bobrov and M. V. Smarkov
Year:
1977
Bibliographic source:
Pharmaceutical Chemistry Journal, Volume 11, Issue 4, pp 481–483, April 1977
Reference Type:
other: authoritative database
Title:
Acute oral toxicity study of Isonicotinic acid (CAS no: 55-22-1) in Rat.
Author:
U.S. National Library of Medicine
Year:
2017
Bibliographic source:
ChemIDplus, A TOXNET DATABASE, Lite Browse Advanced, 2017
Reference Type:
other: authoritative database
Title:
Acute oral toxicity study of Isonicotinic acid (CAS no: 55-22-1) in Rat
Author:
IFA GESTIS
Year:
2017
Bibliographic source:
IFA GESTIS, GESTIS SUBSTANCE Database, 2017

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: as metioned below
Principles of method if other than guideline:
Acute oral toxicity of Isonicotinic acid (CAS no: 55-22-1) in rats.
GLP compliance:
not specified
Test type:
other: not specified
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Isonicotinic acid
EC Number:
200-228-2
EC Name:
Isonicotinic acid
Cas Number:
55-22-1
Molecular formula:
C6H5NO2
IUPAC Name:
Isonicotinic acid
Details on test material:
Name - Isonicotinic acid
Molecular formula - C6H5NO2
Molecular weight - 123.1105 g/mole
Substance type - Organic
Smiles - OC(=O)c1ccncc1
InChI - 1S/C6H5NO2/c8-6(9)5-1-3-7-4-2-5/h1-4H,(H,8,9)
Specific details on test material used for the study:
Name - Isonicotinic acid
Molecular formula - C6H5NO2
Molecular weight - 123.1105 g/mole
Substance type - Organic
Physical state - fine-crystalline cream-yellow powder
Smiles - OC(=O)c1ccncc1
InChI - 1S/C6H5NO2/c8-6(9)5-1-3-7-4-2-5/h1-4H,(H,8,9)

Test animals

Species:
rat
Strain:
other: White rat
Sex:
not specified
Details on test animals or test system and environmental conditions:
not specified

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
not specified
Details on oral exposure:
not specified
Doses:
5000 mg/kg
No. of animals per sex per dose:
not specified
Control animals:
not specified
Details on study design:
- Other examinations performed: Animals were observed for clinical signs.
Statistics:
not specified

Results and discussion

Preliminary study:
not specified
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
5 000 mg/kg bw
Based on:
test mat.
Remarks on result:
other: 50% mortality was observed
Mortality:
50% mortality was observed at 5000 mg/kg
Clinical signs:
other: Clinical signs such as, suppression of the general motor activity, an impairment of motor coordination of the animal, and its assumption of a lateral position was observed.
Gross pathology:
not specified
Other findings:
not specified

Applicant's summary and conclusion

Interpretation of results:
Category 5 based on GHS criteria
Conclusions:
The LD50 was considered to be 5000 mg/kg bw, when white rats were treated with Isonicotinic acid (CAS no: 55-22-1) via oral gavage route.
Executive summary:

The acute oral toxicity of Isonicotinic acid (CAS no: 55-22-1) was tested inrats at the dose concentration of 5000 mg/kg bw. Animals were observed for clinical signs. 50% mortality was observed at 5000 mg/kg with clinical signs such as, suppression of the general motor activity, an impairment of motor coordination of the animal, and its assumption of a lateral position was observed. Therefore, LD50 was considered to be 5000 mg/kg bw, when white rats were treated with Isonicotinic acid via oral gavage route.