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EC number: 615-229-7 | CAS number: 70969-57-2
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study similar to guideline with acceptable restrictions (limited information on test substance, applied volume (1.5 mL/100 g bw) exceeds the recommended value).
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Version / remarks:
- Adopted 24 February 1987
- Deviations:
- yes
- Remarks:
- limited information on test substance, applied volume (1.5 mL/100 g bw) exceeds the recommended value
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 2,2-bis[[(1-oxoisooctadecyl)oxy]methyl]-1,3-propanediyl bis(isooctadecanoate)
- EC Number:
- 263-423-1
- EC Name:
- 2,2-bis[[(1-oxoisooctadecyl)oxy]methyl]-1,3-propanediyl bis(isooctadecanoate)
- Cas Number:
- 62125-22-8
- IUPAC Name:
- 62125-22-8
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: CD
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River U.K. Limited, Margate, Kent
- Weight at study initiation: males: 247.2 g ± 3.4 g, females: 201.2 g ± 9.0 g
- Fasting period before study: overnight before dosing
- Housing: in single sex groups in polypropylene cages
- Diet: smodified 41B diet, Pilsbury´s Limited, Birmingham, UK, ad libitum
- Water: ad libitum
ENVIRONMENTAL CONDITIONS
controlled temperature and lighting conditions
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- vegetable oil
- Details on oral exposure:
- VEHICLE
- Amount of vehicle: 15 mL/kg bw
- Purity: no data
MAXIMUM DOSE VOLUME APPLIED: 15 mL/kg bw - Doses:
- 10.000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: animals were examined immediately and 4 h after dosing and then daily.
- Necropsy of survivors performed: no
- Other examinations performed: clinical signs
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 10 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality occurred during the study period.
- Clinical signs:
- other: All the rats were hypoactive at the 4 h observation period. No further signs of toxicity were noted during the study period.
Applicant's summary and conclusion
- Interpretation of results:
- other: CLP/EU GHS criteria not met, no classification required according to Regulation (EC) No. 1272/2008.
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