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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

An in vitro skin corrosion assay according to OECD guideline 431 is available for TPnB-highers.

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Additional information

TPnB-H Glycol Ether was evaluated for skin corrosivity potential in an EpiDerm In Vitro corrosion assay which utilizes cultured human epidermal cells. In this assay, test material was topically applied to a three-dimensional regenerated human epidermis tissue for three minutes or one hour. Skin corrosion potential of the test substance was classified according to tissue viability following exposure. A test substance is considered corrosive if the mean viability is less than 50% after three minutes or ≥ 50% at three minutes but less than 15% after one hour. The mean tissue viability of DOWANOL™ TPnB-H Glycol Ether treatment following the three minute and one hour exposure periods were 89.2% and 92.6% respectively. Therefore, using the EpiDerm prediction model for corrosion DOWANOL™ TPnB-H Glycol Ether was classified as non-corrosive.

No eye irritation test has been conducted with TPnB-highers as the reaction mass contains up to 2 % potassium hydroxide and is therefore classified for skin and eye irritation.

Effects on skin irritation/corrosion: irritating

Effects on eye irritation: irritating

Justification for classification or non-classification

TPnB-H Glycol Ether was classified as non-corrosive based on the results from an in vitro model for skin corrosion. Due to residual alkalinity (potassium hydroxide) and pH >11.5 TPnB-highers are classified for skin and eye irritation.