Registration Dossier
Registration Dossier
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EC number: 500-003-1 | CAS number: 9003-13-8
Endpoint summary
Administrative data
Description of key information
GLP-studies according to OECD guidelines 423 and 402 are available for tripropylene glycol butyl ether highers (TPnB-H).
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 300 mg/kg bw
Acute toxicity: via dermal route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Additional information
Oral: an acute oral toxicity test (Acute Toxic Class Method) was conducted with Fischer 344 rats to determine the potential for Dowanol™ TPnB-H Glycol Ether to produce toxicity from a single dose via the oral route. Under the conditions of this study, the acute oral LD50 of Dowanol™ TPnB-H Glycol Ether is estimated to be between 300 and 2,000 mg/kg of body weight in female rats.
Dermal: an acute dermal toxicity test was conducted with Fischer 344 rats to determine the potential for Dowanol TPnB-H Glycol Ether to produce toxicity from a single topical application. Under the conditions of this study, the single dose acute dermal LD50 of the test substance was greater than 2,000 mg/kg of body weight in male and female rats.
Inhalation: no study for acute inhalation toxicity has been conducted with TPnB-H as inhalation exposure is unlikely due to the low vapor pressure
(<0.01 mbar at 20°C).
Justification for classification or non-classification
Tripropylene glycol butyl ether highers (TPnB-H) should be classified as harmful via the oral route - according to EU criteria - based on an estimated oral LD50 between 300 and 2000 mg/kg bw in rats.
The dermal LD50 of TPnB-H is greater than 2000 mg/kg bw. Hence, no classification for acute dermal toxicity is required according to EU criteria.
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