Registration Dossier
Registration Dossier
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EC number: 205-840-3 | CAS number: 155-04-4
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: limited but acceptable documented study report which meets basic scientific principles
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 975
- Report date:
- 1975
Materials and methods
- Principles of method if other than guideline:
- Method: other: in vivo eye irritation study (100 mg was placed into the conjunctival sac of 6 rabbits; 7-d observation period)
- GLP compliance:
- no
Test material
- Reference substance name:
- Zinc di(benzothiazol-2-yl) disulphide
- EC Number:
- 205-840-3
- EC Name:
- Zinc di(benzothiazol-2-yl) disulphide
- Cas Number:
- 155-04-4
- Molecular formula:
- C7H5NS2.1/2Zn
- IUPAC Name:
- zinc 1,3-benzothiazole-2-thiolate
- Details on test material:
- Bantex
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Duration of treatment / exposure:
- 24 h
- Observation period (in vivo):
- 7 d
- Number of animals or in vitro replicates:
- 6
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 24, 48, 72 h
- Score:
- 1.8
- Max. score:
- 110
- Reversibility:
- fully reversible within: 48 h
- Remarks on result:
- other: slight erythema and slight to copious discharge
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 1 h
- Score:
- 7.3
- Max. score:
- 110
- Reversibility:
- fully reversible within: 48 h
- Remarks on result:
- other: slight erythema, moderate to copious dischage
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 24 h
- Score:
- 5.3
- Max. score:
- 110
- Reversibility:
- fully reversible within: 48 h
- Remarks on result:
- other: slight erythema, slight to moderate discharge
Any other information on results incl. tables
Immediate: discomfort
10 minutes: slight erythema, slight discharge
1 hour: slight erythema, moderate to copious discharge
24 hours: slight erythema, slight to moderate discharge
48 hours: all scored zero
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information
- Executive summary:
The eye irritating potential of the test substance ZMBT was evaluated in an eye irritation study with six New Zealand albino rabbits. The finely ground test substance (100 mg) was placed into eyes of six rabbits. A 7-day observation period followed the application of the test substance. Eye response were scored in accordance with the Federal Hazardous substances Act (F.H.S.A.), 21 CFR, § 191.12 (1964).
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