Registration Dossier
Registration Dossier
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EC number: 203-128-7 | CAS number: 103-61-7
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- data is from peer reviewed journals
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Fragrance material review on cinnamyl butyrate
- Author:
- S.P. Bhatia, G.A. Wellington, J. Cocchiara, J. Lalko, C.S. Letizia, A.M. Api
- Year:
- 2 007
- Bibliographic source:
- Food and Chemical Toxicology, 45, (2007), S62–S65
- Reference Type:
- publication
- Title:
- A toxicologic and dermatologic assessment of related esters and alcohols of cinnamic acid and cinnamyl alcohol when used as fragrance ingredients
- Author:
- D. Belsito, D. Bickers , M. Bruze , P. Calow , H. Greim ,J.M. Hanifin, A.E. Rogers , J.H. Saurat, I.G. Sipesi, H. Tagami
- Year:
- 2 007
- Bibliographic source:
- Food and Chemical Toxicology, 45, (2007) S1–S23
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- The acute dermal irritation of cinnamyl butyrate was evaluated as a part of the acute dermal LD50 study.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Cinnamyl butyrate
- EC Number:
- 203-128-7
- EC Name:
- Cinnamyl butyrate
- Cas Number:
- 103-61-7
- Molecular formula:
- C13H16O2
- IUPAC Name:
- cinnamyl butyrate
- Test material form:
- liquid
- Details on test material:
- - Name of the test material: Cinnamyl butyrate
- IUPAC name: (2E)-3-phenylprop-2-en-1-yl butanoate
- Molecular formula: C13H16O2
- Molecular weight: 204.267 g/mol
- Substance type: Organic
- Smiles: c1(\C=C\COC(CCC)=O)ccccc1
- InChI : 1S/C13H16O2/c1-2-7-13(14)15-11-6-10-12-8-4-3-5-9-12/h3-6,8-10H,2,7,11H2,1H3/b10-6+
- Substance typy : Organic
- Physical State: Colorless to yellowish liquid
Constituent 1
- Specific details on test material used for the study:
- - Name of the test material: Cinnamyl butyrate
- IUPAC name: (2E)-3-phenylprop-2-en-1-yl butanoate
- Molecular formula: C13H16O2
- Molecular weight: 204.267 g/mol
- Substance type: Organic
- Smiles: c1(\C=C\COC(CCC)=O)ccccc1
- Physical State: Colorless liquid
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or test system and environmental conditions:
- no data available
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: intact skin
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- 5000 mg/kg
- Duration of treatment / exposure:
- 24 hours, single dermal exposure
- Observation period:
- 14 days
- Number of animals:
- 4
- Details on study design:
- no data available
Results and discussion
In vitro
- Other effects / acceptance of results:
- no data available
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 14 d
- Reversibility:
- fully reversible within: 24 hours
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- Erythema was the only effect observed which lasted only for 24 hours.
Applicant's summary and conclusion
- Interpretation of results:
- other: not irritating
- Conclusions:
- Erythema was the only effect observed which lasted only for 24 hours. Since the effects were reversible after 24 hours, Cinnamyl butyrate can be considered to be not irritating to rabbit skin.
- Executive summary:
The acute dermal irritation of cinnamyl butyrate was evaluated as a part of the acute dermal LD50 study. 4 rabbits were received a single dermal application of 5000mg/kg of cinnamyl butyrate for 24 hours under occlusive conditions. Observations were made for 14 days.
Erythema was the only effect observed which lasted only for 24 hours. Since the effects were reversible after 24 hours, Cinnamyl butyrate can be considered to be not irritating to rabbit skin.
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