Registration Dossier
Registration Dossier
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EC number: 212-602-2 | CAS number: 831-51-6
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation / corrosion, other
- Type of information:
- (Q)SAR
- Adequacy of study:
- other information
- Study period:
- 2017
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- accepted calculation method
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: REACH Guidance on QSARs v.3.4
- GLP compliance:
- no
Test material
- Reference substance name:
- 3-amino-2-hydroxy-5-nitrobenzoic acid
- EC Number:
- 212-602-2
- Cas Number:
- 831-51-6
- Molecular formula:
- C7H6N2O5
- IUPAC Name:
- 3-amino-2-hydroxy-5-nitrobenzoic acid
- Test material form:
- solid: particulate/powder
Constituent 1
Test animals
- Species:
- rabbit
Results and discussion
Any other information on results incl. tables
Estimation
method: Takes mode value from the 5 nearest neighbours
Domain logical expression:Result: In Domain
(("a"
and "b" )
and ("c"
and "d" )
)
Domain
logical expression index: "a"
Referential
boundary: The
target chemical should be classified as Aromatic amines AND Phenols by
Skin irritation/corrosion Inclusion rules by BfR
Domain
logical expression index: "b"
Similarity
boundary:Target:
Nc1cc(N(=O)=O)cc(C(O)=O)c1O
Threshold=20%,
Dice(Atom pairs;Atom centered fragments)
Atom type; Count H attached; Hybridization
Domain
logical expression index: "c"
Parametric
boundary:The
target chemical should have a value of log Kow which is >= 0.236
Domain
logical expression index: "d"
Parametric
boundary:The
target chemical should have a value of log Kow which is <= 3.94
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information
- Conclusions:
- Based on the analysis using OECD QSAR Toolbox, the substance is considered as non-irritating to skin.
- Executive summary:
Based on the analysis using OECD QSAR Toolbox, the substance is considered as non-irritating to skin.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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