Registration Dossier
Registration Dossier
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EC number: 200-752-1 | CAS number: 71-41-0
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
The short term toxicity to aquatic invertebrates was evaluated using a weight of evidence approach. The 48 h-EC50 value of 255 mg /L determined in a study conducted with the read-across substance 3-methylbutan-1-ol according to DIN 38412 L11 was chosen as key parameter. In addition study results are available for all the other category members, all revealing EC50 values well above 100 mg/L.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 255 mg/L
Additional information
In the acute immobilization test with Daphnia magna (STRAUS), the effects of the test substance with a nominal loading of 0 0, 15.625, 31.3, 62.5, 125, 250, and 500 mg test item/L and a control (0 mg test item/L) were determined according to Regulation (EC) No 79/831/C2 under non GLP conditions (BASF 1990). No concentrations were analytically measured. The number of the organisms per vessel was 5. The mobility of the Daphnia was determined in a static 48-hour test by visual observation after 3, 6, 24 and 48 hours. The 48h-EC50 value was determined to be nominal 341 mg test item/L.
In addition, the acute toxicity of the surrogate test substance 2-methylbutan-1-ol on aquatic invertebrates was investigated under GLP conditions according to OECD 202 (BASF 2011). The 48h-EC50 value was determined to be greater than 173 mg/L (value based on measured concentration).
Supplementary the acute toxicity of the surrogate test substance 3-methylbutan-1-ol to Daphnia magna was assessed according to DIN 38412 L11 (BASF 1990). The 48 h-EC50 value was determined to be nominal 255 mg test item/L.
Study results are also available for the fourth category member pentanol, branchend and linear. The EC50 value of this substance was determined to be greater than 120 mg/L in a GLP guideline study with Daphnia magna according to OECD 202 (BASF 2011).
In conclusion, the 48h-EC50 value of the test substance and of the read across category members was determined to be greater than 100 mg/L. As the EC50 value determined with the read-across substance 3-methylbutan-1-ol was lower than the EC50 value determined in the study with the target substance itself, the smaller value was chosen as “key value” and used for PNEC derivation, reflecting a worst-case scenario.
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