Violet sodium polysulfide aluminosilicate with a SOD-type framework structure

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

26 August 2020 to 04 September 2020

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Deviations:

no

Qualifier:

according to guideline

Guideline:

EPA OPPTS 830.7840 (Water Solubility)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

flask method

Key result

Water solubility:

24.45 mg/L

Conc. based on:

element

Remarks:

Aluminium

Incubation duration:

72 h

Temp.:

20 °C

pH:

8

Details on results:

The solubility of the test substance was found to be 2.89 mg/L for 24 hours, 3.40 mg/L for 48 hours and 3.21 mg/L for 72 hours respectively in terms of Aluminium content and the solubility of the test substance was found to be 22.32 mg/L for 24 hours, 26.25 mg/L for 48 hours and 24.79 mg/L for 72 hours respectively, based on the 12.30% of Aluminium content in the test item which are within the limit of concentration measured in the last two conical flasks (48 hours and 72 hours) as they do not differ by more than 15%.

Table 1. Determination of precision (% RSD) and accuracy (% recovery)

Sample Code	Conc. of Sample for Aluminium (ppb)	Sample Volume  Taken (mL)	Final Sample Volume  (mL)	Dilution Factor	Conc. Obtained for Aluminium (ppb)	Conc. Obtained for Aluminium (mg/L)	Nominal Conc. for Aluminium (mg/L)	Recovery (%)	Mean Recovery (%)	SD (±)	RSD (%)
Control 1	LLOQ	3.0	50.0	1.0	-	-	-	-	-	-	-
ACC 1 R1	38.67	3.0	50.0	1.0	644.50	0.64	0.69	93.41	91.73	1.25	1.36
ACC 1 R2	38.35	3.0	50.0	1.0	639.17	0.64	0.69	92.63
ACC 1 R3	37.45	3.0	50.0	1.0	624.17	0.62	0.70	90.46
ACC 1 R4	37.62	3.0	50.0	1.0	627.00	0.63	0.70	90.87
ACC 1 R5	37.78	3.0	50.0	1.0	629.67	0.63	0.70	91.26
Control 2	LLOQ	3.0	50.0	1.0	-	-	-	-	-	-	-
ACC2 R1	44.72	3.0	50.0	10.0	7453.33	7.45	6.93	107.55	94.97	11.37	11.97
ACC2 R2	44.60	3.0	50.0	10.0	7433.33	7.43	6.94	107.26
ACC2 R3	35.85	3.0	50.0	10.0	5975.00	5.98	6.99	86.22
ACC2 R4	35.77	3.0	50.0	10.0	5961.67	5.96	6.97	86.03
ACC2 R5	36.50	3.0	50.0	10.0	6083.33	6.08	7.02	87.78

 

Table 2. Determination of water solubility of ultramarine violet pigment violet 15 CI 77007 (24, 48 and 72 hours)

Sample Code	Conc. of Sample for Aluminium (ppb)	Dilution Factor	Conc. Obtained for Aluminium (ppb)	Conc. Obtained for Aluminium (mg/L)	Mean Conc. Obtained for Aluminium (mg/L)
24-Hours
Sample 1 24 hours	57.21	50.0	2860.50	2.86	2.89
Sample 2 24 hours	58.21	50.0	2910.50	2.91
48-Hours
Sample 1 48 hours	67.73	50.0	3386.50	3.39	3.40
Sample 2 48 hours	68.10	50.0	3405.00	3.41
72-Hours
Sample 1 72 hours	64.83	50.0	3241.50	3.24	3.21
Sample 2 72 hours	63.52	50.0	3176.00	3.18

 

Table 3. Mean water solubility of ultramarine violet pigment violet 15 CI 77007

Hours	Aluminium Water Solubility (mg/L)
24 hours	2.89
48 hours	3.40
72 hours	3.21
Average	3.16
SD (±)	0.26
(%) RSD	8.00

Conclusions:

The solubility of the test substance in water was determined to be 24.45 mg/L at 20ºC, based on the aluminium content determination of 3.17 mg/L in water and 12.95% of aluminium content in the test item.

Executive summary:

The water solubility determination of the test item was performed in accordance with OECD TG 105 under GLP conditions. In a preliminary test, the solubility of test item was determined to be ≥10-2 g/L, hence the shake flask method was chosen to determine the solubility in the main test. The water solubility of the test substance was assessed by the quantification of aluminium content in the test item. Aluminium content in obtained samples was determined by Inductively coupled plasma mass spectrometry (ICP-MS). Then, the solubility of the test substance in water was determined based on 12.95% content of aluminium in the test substance. The validation of the analytical method was done based on SANCO/3029/99, rev 4.0 and all parameters assessed were within the acceptability criteria. The mean solubility of the test item was determined to be 3.17 mg/L in terms of aluminium content with 4.49% RSD. The mean total solubility of the test substance was determined to be 24.45 mg/L at 20ºC with 8.14% RSD, based on the 12.95% of aluminium content in the test item. The pH was found to be 8.0.

Description of key information

Key study: Test method OECD 105. GLP study. The solubility of the test item in distilled water at pH 8 was determined to be 24.45 mg/L at 20ºC.

Key value for chemical safety assessment

Water solubility:

24.45 mg/L

at the temperature of:

20 °C