Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 910-356-7 | CAS number: -
Developmental toxicity / teratogenicity
Administrative data
- Endpoint:
- developmental toxicity
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- no title available
- Author:
- RTECS
- Year:
- 2 003
- Reference Type:
- review article or handbook
- Title:
- SIDS Initial Risk Assessment of Manganese Dioxide
- Author:
- OECD (Korea)
- Year:
- 2 012
- Bibliographic source:
- OECD Existing Chemicals Database; http://webnet.oecd.org/Hpv/UI/SIDS_Details.aspx?id=B7C06498-8B35-4EA5-9AD3-23188F3AD8FB
Materials and methods
- Principles of method if other than guideline:
- not specified
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Manganese dioxide
- EC Number:
- 215-202-6
- EC Name:
- Manganese dioxide
- Cas Number:
- 1313-13-9
- Molecular formula:
- MnO2
- IUPAC Name:
- Manganese dioxide
- Test material form:
- solid
Constituent 1
Test animals
- Species:
- mouse
Administration / exposure
- Route of administration:
- inhalation
Results and discussion
Results (fetuses)
Effect levels (fetuses)
- Dose descriptor:
- other: TCLo
- Remarks:
- (as mentioned in the secondary source)
- Effect level:
- 143 mg/m³ air
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- fetal/pup body weight changes
- other: behavioural changes (no further details)
- Remarks on result:
- other:
Applicant's summary and conclusion
- Conclusions:
- Mice were xposed to manganese dioxide by inhalation from 75 days of pre-pregnancy to gestation day 1 to 8. A TCLo in mice was determined to be 143 mg/m³/day due to reduced weight gains and behavioural changes in newborns.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
