Registration Dossier

Physical & Chemical properties

Endpoint summary

Administrative data

Description of key information

Additional information

The substance is an UVCB dark brown powder with a characteristic odour.

In a DSC analysis showed decomposition beginning at 278 °C.

Relative density was determined by means of a pycnometer OECD 109 and the result value was D at 20 °C: 1.7251 at 20 °C.

 Granulometry is of considerable importance for the toxic properties of a substance as it influences aspects such as: the route of exposure of humans and toxicity by inhalation; the choice of route of administration for animal testing; the efficiency of uptake in an organism; the distribution in the environment. The substance presented a granulometry mass median aerodynamic diameter (MMAD)= 108.9 µm.

<1% in volume of the test item has a particle size <= 4 µm (respirable fraction (the mass fraction of particles that reaches the alveoli).

The CEN document, EN 481 ‘Workplace Atmospheres – size fraction definitions for measurement of airborne particles’ (CEN 1993) provides definitions of the inhalable, thoracic and respirable size fractions, and target specifications (conventions) for sampling instruments to measure these fractions. The current standard defines sampling conventions for particle size fractions which are to be used in assessing the possible health effects resulting from inhalation of airborne particles in the workplace. The different particle sizes defined in EN 481 are:

- inhalable fraction (the mass fraction of particles that can be inhaled by nose and mouth. Particles >100 μm are not included in the inhalable convention; thoracic fraction (the mass fraction of the inhaled particles that passes the larynx). The convention for thoracic fraction sets that 50% of the particles in air with an aerodynamic diameter of 10 μm belong to the thoracic fraction;

- respirable fraction (the mass fraction of the inhaled particles that reaches the alveoli). The convention for respirable fraction sets that 50% of particles with an aerodynamic diameter of 4 μm belong to the respirable fraction.)

According to Annex VII of REACH Regulation 1907/2006, column 2, the study of vapour pressure does not need to be conducted for this substance but the lowest value accepted by EUSES has been reported for a complete Risk assessment (0.0000001 Pa).

Partition coefficient was determined in HPLC and was stated as < 0.3 (log Pow). The tested substance is considered very soluble (76.63 ± 3.47 g/L).

According to Annex VII of REACH Regulation 1907/2006, column 2 no surface activity is expected or can be predicted; therefore the testing can be waived. As solid, the substance has no a flash point and the test can also be waived. It is not expected to be auto-flammable, flammable, explosive and it is deemed to be potentially not oxidising based on the chemical structure, the oxygen balance values and the known experience in the handling and use of the substance.

Justification for Read Across with Similar substance 01 is detailed in the section summary and it is further detailed in the report attached to the IUCLID section 13.