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Physical & Chemical properties

Melting point / freezing point

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Reference
Endpoint:
melting point/freezing point
Type of information:
experimental study
Adequacy of study:
key study
Study period:
18 June 2015 - 27 November 2015
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
EU Method A.1 (Melting / Freezing Temperature)
Version / remarks:
(2008)
Deviations:
no
Qualifier:
according to
Guideline:
OECD Guideline 102 (Melting point / Melting Range)
Version / remarks:
(1995)
Deviations:
no
Qualifier:
according to
Guideline:
EPA OPPTS 830.7200 (Melting Point / Melting Range)
Version / remarks:
(1998)
Deviations:
no
GLP compliance:
yes
Type of method:
differential scanning calorimetry
Key result
Melting / freezing pt.:
43 °C
Decomposition:
yes
Decomp. temp.:
150 °C
Remarks on result:
other: Melt. pt: 316 K. Decomp. temp: 423 K.

TGA EXPERIMENT

Starting at 200°C, the weight of the sample decreased significantly. At 223°C, the sample weight had decreased by 25%. After the experiment it was observed that the test substance had evaporated from the sample container.

 

DSC EXPERIMENT 1

An endothermic effect with two peaks between 25°C and 100°C was observed. The extrapolated onset temperature of the first peak could not be determined since it was observed within 2 minutes from the start of the experiment. The effect was most likely obtained due to melting of the test substance (first peak) and evaporation of water (second peak). A third endothermic peak was observed between 175°C and 275°C. The effect was most likely obtained due to reaction and/or decomposition of the test substance. After the experiment it was observed that the test substance had evaporated from the sample container.

 

DSC EXPERIMENT 2

To investigate the melting peak between 25°C and 100°C, a repeated heating cycle was applied. The experiment also started at a lower temperature in order to determine the extrapolated onset temperature of the melting peak. With the first heating, the extrapolated onset temperature of the melting peak was 42.75°C. During cooling, no effects were observed which were due to crystallization of the test substance. With the second heating, an exothermic effect with two peaks was observed between -25°C and 25°C. The effect was obtained due to crystallization of the test substance. The extrapolated onset temperature of the melting peak was 43.01°C but this value was not used for calculation of the melting temperature, since it was obtained for melting of non-original test substance. After the experiment, a colourless molten residue remained in the sample container.

 

DSC EXPERIMENT 3

Experiment 3 was performed to obtain a duplicate value for the melting temperature of the test substance. In order to investigate the reaction and/or decomposition peak a lower heating rate was applied from 100°C. The extrapolated onset of the melting peak was 43.63°C.The endothermic reaction and/or decomposition peak shifted to lower temperatures (starting now at 150°C). It demonstrated that reaction and/or decomposition of the test substance was the reason for the endothermic effect. After the experiment, it was observed that the test substance had evaporated from the sample container.

Conclusions:
Using differential scanning calorimetry, the melting temperature of the substance has been determined as 43°C. Reaction and/or decomposition started at 150°C.
The study was performed in accordance with EC A.1, OECD 102 and EPA OPPTS 830.7200 guidelines and in compliance with GLP.

Description of key information

Using differential scanning calorimetry, the melting temperature of the substance has been determined as 43°C. Reaction and/or decomposition started at 150°C. The study was performed in accordance with EC A.1, OECD 102 and EPA OPPTS 830.7200 guidelines and in compliance with GLP.  

Key value for chemical safety assessment

Melting / freezing point at 101 325 Pa:
43 °C

Additional information