Registration Dossier
Registration Dossier
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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 910-388-1 | CAS number: -
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
The contact hypersensitivity potential of Silica-Zirkonia Filler was tested in a Local Lymph Node Assay according to OECD Guideline 429. Groups of five female CBA/J mice were treated with test substance concentrations of 0, 10, 25 or 50% w/w suspended in propylene glycol. The solid test substance was not soluble in this vehicle. No skin irritation was observed. Measurement of radioactivity resulted in Stimulation Indices of 1.6, 1.4 and 1.3 for the three different test substance concentrations.
Migrated from Short description of key information:
No sensitising potential was observed in a local lymph node assay.
Justification for classification or non-classification
No classification is warranted according to DSD (67/548/EEC) and CLP (1272/2008/EC), respectively.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
