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EC number: 244-168-5
CAS number: 21041-95-2
Cadmium compounds have been shown to
induce genetic changes both in vitro and in vivo. There is considerable
evidence to suggest that that the primary mechanism of genotoxicity is
based upon the production of oxidative lesions.On the assumption of an
oxidative mechanism for the genotoxicity of cadmium compounds we can
predict that there may be thresholds of genotoxicity at low doses where
DNA repair enzymes remove lesions thus reducing the potential for
genetic changes in cells and animals.
However, there are some studies which
indicate that cadmium compounds inhibit repair activity which may limit
activity within potential thresholded regions of the dose response curve.
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