Registration Dossier
Registration Dossier
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EC number: 250-205-6 | CAS number: 30449-81-1
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
- Principles of method if other than guideline:
- BASF-Testing method
- GLP compliance:
- no
Test material
- Reference substance name:
- p-[(5-cyano-1,6-dihydro-2-hydroxy-1,4-dimethyl-6-oxo-3-pyridyl)azo]-N-(2-ethylhexyl)benzamide
- EC Number:
- 250-205-6
- EC Name:
- p-[(5-cyano-1,6-dihydro-2-hydroxy-1,4-dimethyl-6-oxo-3-pyridyl)azo]-N-(2-ethylhexyl)benzamide
- Cas Number:
- 30449-81-1
- Molecular formula:
- C23H29N5O3
- IUPAC Name:
- p-[(5-cyano-1,6-dihydro-2-hydroxy-1,4-dimethyl-6-oxo-3-pyridyl)azo]-N-(2-ethylhexyl)benzamide
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Housing: single
- Diet: Altromin standard diet ad libitum
- Water: tap ad libitum
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- not specified
- Vehicle:
- water
- Remarks:
- 50% aq. solution
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 mL - Duration of treatment / exposure:
- Back: 1, 5, 15 minutes; 20 hours
Ear: 20 h - Observation period:
- 24 h, 8 d
- Number of animals:
- 3
- Details on study design:
- TEST SITE
- Area of exposure: back and ear
- % coverage: -
- Type of wrap if used: -
SCORING SYSTEM:
Erythema and Edema
Ø - no effect
(+) - questionable
+ - mild
++ - moderate
+++ - marked
N - necrosis
Sch - scabbing
Na - scar
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24 h / 8 d
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24 h / 8 d
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- No signs of skin irritation
Any other information on results incl. tables
Parameters evaluated:
reddening, edema, scabbing, necrosis, scarification
Descriptors:
questionable, minimal, moderate, marked, without effect
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The test item is not irritating to skin (rabbit). The substance is not classifiable according to CLP criteria.
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