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Physical & Chemical properties

Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.8 (Partition Coefficient - Shake Flask Method)
Deviations:
no
GLP compliance:
yes
Type of method:
other: Shake flask method
Partition coefficient type:
octanol-water
Analytical method:
high-performance liquid chromatography
Key result
Type:
log Pow
Partition coefficient:
3.68
Temp.:
20 °C
pH:
6.93
Conclusions:
log Pow: 3.68 ± 0.01 at 20 ± 1°C
Executive summary:

The study was conducted to determine the partition coefficient of the test substance. The partition coefficient was determined according to regulatory guidelines: OECD Guidelines for the Testing of Chemicals: Partition Coefficient (n-Octanol/Water): Shake Flask Method, Test Guideline 107 and EEC A.8.

The mean partition coefficient, (log Pow) of the test substance was 3.69 ± 0.01, 3.69 ± 0.00 and 3.68 ± 0.01 for octanol-water ratios of 1:1, 1:2 and 2:1, respectively, at 20 ± 1°C.

The overall mean partition coefficient (log Pow) of the test substance was 3.68 ± 0.01 at 20 ± 1°C.

Description of key information

OECD Guideline 107

Key value for chemical safety assessment

Log Kow (Log Pow):
3.68
at the temperature of:
20 °C

Additional information